Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

2018

Mattsson, Niklas

Groot, Colin

Jansen, Willemijn J

Landau, Susan

Villemagne, Victor

Engelborghs, Sebastiaan

Mintun, Mark

Lleo, Alberto

Molinuevo, José Luis

Jagust, William

Frisoni, Giovanni B

Ivanoiu, Adrian

Chételat, Gaël

Resende de Oliveira, Catarina

Rodrigue, Karen M

Kornhuber, Johannes

Wallin, Anders

Klimkowicz-Mrowiec, Aleksandra

Kandimella, Ramesh

Popp, Julius

Aalten, Pauline P

Aarsland, Dag

Alcolea, Daniel

Almdahl, Ina S

Baldeiras, Inês

van Buchem, Mark A

Cavedo, Enrica

Chen, Kewei

Cohen, Ann D

Förster, Stefan

Fortea, Juan

Frederiksen, Kristian S

Freund-Levi, Yvonne

Gill, Kiran Dip

Gkatzima, Olymbia

Grimmer, Timo

Hampel, Harald

Herukka, Sanna-Kaisa

Johannsen, Peter

van Laere, Koen

de Leon, Mony

Maier, Wolfgang

Marcusson, Jan

Meulenbroek, Olga

Møllergård, Hanne M

Morris, John C

Mroczko, Barbara

Nordlund, Arto

Prabhakar, Sudesh

Peters, Oliver

Rami, Lorena

Rodríguez-Rodríguez, Eloy

Roe, Catherine M

Rüther, Eckart

Santana, Isabel

Schröder, Johannes

Seo, Sang W

Soininen, Hilkka

Spiru, Luiza

Stomrud, Erik

Struyfs, Hanne

Teunissen, Charlotte E

Verhey, Frans R J

Vos, Stephanie J B

van Waalwijk van Doorn, Linda J C

Waldemar, Gunhild

Wallin, Åsa K

Wiltfang, Jens

Vandenberghe, Rik

Brooks, David J

Fladby, Tormod

Rowe, Christopher C

Drzezga, Alexander

Verbeek, Marcel M

Sarazin, Marie

Wolk, David A

Fleisher, Adam S

Klunk, William E

Na, Duk L

Sánchez-Juan, Pascual

Lee, Dong Young

Nordberg, Agneta

Tsolaki, Magda

Camus, Vincent

Rinne, Juha O

Fagan, Anne M

Zetterberg, Henrik

Blennow, Kaj

Rabinovici, Gil D

Hansson, Oskar

van Berckel, Bart N M

van der Flier, Wiesje M

Scheltens, Philip

Visser, Pieter Jelle

Ossenkoppele, Rik

APOE

Age

Alzheimer's disease

Amyloid

CSF

Education

Geographical location

Mild cognitive impairment

PET

Prevalence

Sex

Subjective cognitive decline

Journal Article

0000-0003-3910-2453

10.1016/j.jalz.2018.02.009

Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location. The APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in Aβ+ cognitively normal and Aβ+ mild cognitive impairment (P < .05) but not in Aβ+ AD dementia (P = .66). The prevalence was highest in Northern Europe but did not vary by sex or education. The APOE ε4 prevalence in AD was higher than that in previous studies, which did not require presence of Aβ pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.

link

Alzheimer's & dementia 2018; 14(7): 913-924

Alzheimer's & dementia