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dc.contributor.authorMattsson, Niklas-
dc.contributor.authorGroot, Colin-
dc.contributor.authorJansen, Willemijn J-
dc.contributor.authorLandau, Susan-
dc.contributor.authorVillemagne, Victor-
dc.contributor.authorEngelborghs, Sebastiaan-
dc.contributor.authorMintun, Mark-
dc.contributor.authorLleo, Alberto-
dc.contributor.authorMolinuevo, José Luis-
dc.contributor.authorJagust, William-
dc.contributor.authorFrisoni, Giovanni B-
dc.contributor.authorIvanoiu, Adrian-
dc.contributor.authorChételat, Gaël-
dc.contributor.authorResende de Oliveira, Catarina-
dc.contributor.authorRodrigue, Karen M-
dc.contributor.authorKornhuber, Johannes-
dc.contributor.authorWallin, Anders-
dc.contributor.authorKlimkowicz-Mrowiec, Aleksandra-
dc.contributor.authorKandimella, Ramesh-
dc.contributor.authorPopp, Julius-
dc.contributor.authorAalten, Pauline P-
dc.contributor.authorAarsland, Dag-
dc.contributor.authorAlcolea, Daniel-
dc.contributor.authorAlmdahl, Ina S-
dc.contributor.authorBaldeiras, Inês-
dc.contributor.authorvan Buchem, Mark A-
dc.contributor.authorCavedo, Enrica-
dc.contributor.authorChen, Kewei-
dc.contributor.authorCohen, Ann D-
dc.contributor.authorFörster, Stefan-
dc.contributor.authorFortea, Juan-
dc.contributor.authorFrederiksen, Kristian S-
dc.contributor.authorFreund-Levi, Yvonne-
dc.contributor.authorGill, Kiran Dip-
dc.contributor.authorGkatzima, Olymbia-
dc.contributor.authorGrimmer, Timo-
dc.contributor.authorHampel, Harald-
dc.contributor.authorHerukka, Sanna-Kaisa-
dc.contributor.authorJohannsen, Peter-
dc.contributor.authorvan Laere, Koen-
dc.contributor.authorde Leon, Mony-
dc.contributor.authorMaier, Wolfgang-
dc.contributor.authorMarcusson, Jan-
dc.contributor.authorMeulenbroek, Olga-
dc.contributor.authorMøllergård, Hanne M-
dc.contributor.authorMorris, John C-
dc.contributor.authorMroczko, Barbara-
dc.contributor.authorNordlund, Arto-
dc.contributor.authorPrabhakar, Sudesh-
dc.contributor.authorPeters, Oliver-
dc.contributor.authorRami, Lorena-
dc.contributor.authorRodríguez-Rodríguez, Eloy-
dc.contributor.authorRoe, Catherine M-
dc.contributor.authorRüther, Eckart-
dc.contributor.authorSantana, Isabel-
dc.contributor.authorSchröder, Johannes-
dc.contributor.authorSeo, Sang W-
dc.contributor.authorSoininen, Hilkka-
dc.contributor.authorSpiru, Luiza-
dc.contributor.authorStomrud, Erik-
dc.contributor.authorStruyfs, Hanne-
dc.contributor.authorTeunissen, Charlotte E-
dc.contributor.authorVerhey, Frans R J-
dc.contributor.authorVos, Stephanie J B-
dc.contributor.authorvan Waalwijk van Doorn, Linda J C-
dc.contributor.authorWaldemar, Gunhild-
dc.contributor.authorWallin, Åsa K-
dc.contributor.authorWiltfang, Jens-
dc.contributor.authorVandenberghe, Rik-
dc.contributor.authorBrooks, David J-
dc.contributor.authorFladby, Tormod-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorDrzezga, Alexander-
dc.contributor.authorVerbeek, Marcel M-
dc.contributor.authorSarazin, Marie-
dc.contributor.authorWolk, David A-
dc.contributor.authorFleisher, Adam S-
dc.contributor.authorKlunk, William E-
dc.contributor.authorNa, Duk L-
dc.contributor.authorSánchez-Juan, Pascual-
dc.contributor.authorLee, Dong Young-
dc.contributor.authorNordberg, Agneta-
dc.contributor.authorTsolaki, Magda-
dc.contributor.authorCamus, Vincent-
dc.contributor.authorRinne, Juha O-
dc.contributor.authorFagan, Anne M-
dc.contributor.authorZetterberg, Henrik-
dc.contributor.authorBlennow, Kaj-
dc.contributor.authorRabinovici, Gil D-
dc.contributor.authorHansson, Oskar-
dc.contributor.authorvan Berckel, Bart N M-
dc.contributor.authorvan der Flier, Wiesje M-
dc.contributor.authorScheltens, Philip-
dc.contributor.authorVisser, Pieter Jelle-
dc.contributor.authorOssenkoppele, Rik-
dc.date2018-03-27-
dc.date.accessioned2018-04-05T02:26:47Z-
dc.date.available2018-04-05T02:26:47Z-
dc.date.issued2018-
dc.identifier.citationAlzheimer's & dementia 2018; 14(7): 913-924-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17385-
dc.description.abstractApolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location. The APOE ε4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in Aβ+ cognitively normal and Aβ+ mild cognitive impairment (P < .05) but not in Aβ+ AD dementia (P = .66). The prevalence was highest in Northern Europe but did not vary by sex or education. The APOE ε4 prevalence in AD was higher than that in previous studies, which did not require presence of Aβ pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location.-
dc.language.isoeng-
dc.subjectAPOE-
dc.subjectAge-
dc.subjectAlzheimer's disease-
dc.subjectAmyloid-
dc.subjectCSF-
dc.subjectEducation-
dc.subjectGeographical location-
dc.subjectMild cognitive impairment-
dc.subjectPET-
dc.subjectPrevalence-
dc.subjectSex-
dc.subjectSubjective cognitive decline-
dc.titlePrevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.-
dc.typeJournal Article-
dc.identifier.journaltitleAlzheimer's & dementia-
dc.identifier.affiliationDepartment of Nuclear Medicine, University of Cologne, Cologne, Germanyen
dc.identifier.affiliationDepartment of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UKen
dc.identifier.affiliationUK Dementia Research Institute, London, UKen
dc.identifier.affiliationClinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden-
dc.identifier.affiliationDepartment of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands-
dc.identifier.affiliationDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands-
dc.identifier.affiliationHelen Wills Neuroscience Institute, University of California, Berkeley, CA, USA-
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia-
dc.identifier.affiliationReference Center for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium-
dc.identifier.affiliationAvid Radiopharmaceuticals, Philadelphia, PA, USA-
dc.identifier.affiliationNeurology Department, Hospital de Sant Pau, Barcelona, Spain-
dc.identifier.affiliationAlzheimer's Disease and Other Cognitive Disorders Unit, IDIBAPS, Clinic University Hospital, Barcelona, Spain-
dc.identifier.affiliationMemory Clinic and LANVIE- Laboratory of Neuroimaging of Aging, University Hospitals, and University of Geneva, Geneva, Switzerland-
dc.identifier.affiliationLaboratory of Alzheimer's Neuroimaging and Epidemiology, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy-
dc.identifier.affiliationMemory Clinic and Neurochemistry Laboratory, Saint Luc University Hospital, Institute of Neuroscience, Université catholique de Louvain, Brussels, Belgium-
dc.identifier.affiliationInserm, Inserm UMR-S U1237, Université de Caen-Normandie, GIP Cyceron, Caen, France-
dc.identifier.affiliationCenter for Neuroscience and Cell Biology, Faculty of Medicine, Centro Hospitalar e Universitário de Coimbra, Portugal-
dc.identifier.affiliationCenter for Vital Longevity, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, USA-
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy, Friedrich-Alexander University of Erlangen- Nuremberg, Erlangen, Germany-
dc.identifier.affiliationInstitute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden-
dc.identifier.affiliationJagiellonian University College of Medicine, Krakow, Poland-
dc.identifier.affiliationPostgraduate Institute of Medical Education and Research (PGIMER), Department of Biochemistry, Research Block-A, Chandigarh, India-
dc.identifier.affiliationDepartment of Psychiatry, Service of Old Age Psychiatry, University Hospital of LaUSAnne, LaUSAnne, Switzerland-
dc.identifier.affiliationCenter for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway-
dc.identifier.affiliationDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway-
dc.identifier.affiliationDepartment of Radiology, Leiden University Medical Center, Leiden, the Netherlands-
dc.identifier.affiliationAXA Research Fund & UPMC Chair, Sorbonne Universités, Université Pierre et Marie Curie (UPMC) Paris 06, Inserm, CNRS, Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A), Hôpital Pitié-Salpêtrière, Paris, France-
dc.identifier.affiliationBanner Alzheimer's Institute, Phoenix, AZ, USA-
dc.identifier.affiliationUniversity of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, PA, USA-
dc.identifier.affiliationDepartment of Nuclear Medicine, Technische Universitaet München, Munich, Germany-
dc.identifier.affiliationDanish Dementia Research Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark-
dc.identifier.affiliationDepartment of Geriatrics, Karolinska University Hospital Huddinge, Section of Clinical Geriatrics, Institution of NVS, Karolinska Institutet, Stockholm, Sweden-
dc.identifier.affiliationThird Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece-
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universitaet München, Munich, Germany-
dc.identifier.affiliationDepartment of Psychiatry, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Ludwig-Maximilian University, Munich, Germany-
dc.identifier.affiliationDepartment of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland-
dc.identifier.affiliationMemory Clinic, Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark-
dc.identifier.affiliationDepartment of Imaging and Pathology, Catholic University Leuven, Leuven, Belgium-
dc.identifier.affiliationSchool of Medicine, Center for Brain Health, New York University, New York, NY, USA-
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy, University of Bonn, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany-
dc.identifier.affiliationGeriatric Medicine, Department of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden-
dc.identifier.affiliationDepartment of Geriatric Medicine, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands-
dc.identifier.affiliationKnight Alzheimer's Disease Research Center, Department of Neurology, Washington University School of Medicine, St Louis, MO, USA-
dc.identifier.affiliationDepartment of Neurodegeneration Diagnostics, Leading National Research Centre in Białystok (KNOW), Medical University of Białystok, Białystok, Poland-
dc.identifier.affiliationDepartment of Neurology, Research Block-A, Chandigarh, India-
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy, Charité Berlin, German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany-
dc.identifier.affiliationNeurology Service, Universitary Hospital Marqués de Valdecilla, CIBERNED, IDIVAL, Santander, Spain-
dc.identifier.affiliationDepartment of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany-
dc.identifier.affiliationSektion Gerontopsychiatrie, Universität Heidelberg, Heidelberg, Germany-
dc.identifier.affiliationDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea-
dc.identifier.affiliationDepartment of Geriatrics-Gerontology-Gerontopsychiatry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania-
dc.identifier.affiliationNeurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands-
dc.identifier.affiliationDepartment of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands-
dc.identifier.affiliationDepartment of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, the Netherlands-
dc.identifier.affiliationLaboratory for Cognitive Neurology and Alzheimer Research Centre KU Leuven, Catholic University Leuven, Leuven, Belgium-
dc.identifier.affiliationDivision of Neuroscience, Medical Research Council Clinical Sciences Centre, Imperial College London, London, UK-
dc.identifier.affiliationNeurologie de la Mémoire et du Langage, Centre Hospitalier Sainte-Anne, Université Paris Descartes, Sorbonne Paris Cité, Paris, France-
dc.identifier.affiliationDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, USA-
dc.identifier.affiliationEli Lilly, Indianapolis, IN, USA-
dc.identifier.affiliationDepartment of Neurosciences, University of California, San Diego, CA, USA-
dc.identifier.affiliationDepartment of Neuropsychiatry, Seoul National University, College of Medicine, Seoul, South Korea-
dc.identifier.affiliationDepartment NVS, Center for Alzheimer Research, Translational Alzheimer Neurobiology, Karolinska Institutet and Geriatric Medicine, Karolinska University Hospital, Stockholm, Sweden-
dc.identifier.affiliationCHRU de Tours, CIC INSERM 1415, INSERM U930, Université François Rabelais de Tours, Tours, France-
dc.identifier.affiliationTurku PET Centre and Division of Clinical Neurosciences Turku, University of Turku and Turku University Hospital, Turku, Finland-
dc.identifier.affiliationInstitute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden-
dc.identifier.affiliationSweden and Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden-
dc.identifier.affiliationDepartment of Neurology, Memory and Aging Center, University of California, San Francisco, CA, USA-
dc.identifier.affiliationDepartment of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, the Netherlands-
dc.identifier.affiliationDepartment of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands-
dc.identifier.doi10.1016/j.jalz.2018.02.009-
dc.identifier.orcid0000-0003-3910-2453-
dc.identifier.pubmedid29601787-
dc.type.austinJournal Article-
local.name.researcherRowe, Christopher C
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptMolecular Imaging and Therapy-
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