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Title: Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model
Austin Authors: Lin, Yu-Wei;Zhou, Qi Tony;Han, Mei-Ling;Chen, Ke;Onufrak, Nikolas J;Wang, Jiping;Turnidge, John D;Howden, Benjamin P ;Forrest, Alan;Chan, Hak-Kim;Li, Jian
Affiliation: Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana, USA
Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, Australia
Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, The University of North Carolina, Chapel Hill, North Carolina, USA
Australian Commission on Safety and Quality in Health Care, Sydney, New South Wales, Australia
Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection and Immunity, Melbourne, Victoria, Australia
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australia
Issue Date: 2018
Date: 2017-12-11
Publication information: Antimicrobial Agents and Chemotherapy 2018; 62(2): e01790-17
Abstract: Pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. AUC/MIC in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin.
DOI: 10.1128/AAC.01790-17
Journal: Antimicrobial Agents and Chemotherapy
PubMed URL:
Type: Journal Article
Appears in Collections:Journal articles

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