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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/17035
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dc.contributor.authorLin, Yu-Wei-
dc.contributor.authorZhou, Qi Tony-
dc.contributor.authorHan, Mei-Ling-
dc.contributor.authorChen, Ke-
dc.contributor.authorOnufrak, Nikolas J-
dc.contributor.authorWang, Jiping-
dc.contributor.authorTurnidge, John D-
dc.contributor.authorHowden, Benjamin P-
dc.contributor.authorForrest, Alan-
dc.contributor.authorChan, Hak-Kim-
dc.contributor.authorLi, Jian-
dc.date2017-12-11-
dc.date.accessioned2017-12-14T05:01:13Z-
dc.date.available2017-12-14T05:01:13Z-
dc.date.issued2018-
dc.identifier.citationAntimicrobial Agents and Chemotherapy 2018; 62(2): e01790-17en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/17035-
dc.description.abstractPharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. AUC/MIC in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin.en_US
dc.titleElucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Modelen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleAntimicrobial Agents and Chemotherapyen_US
dc.identifier.affiliationAdvanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationDepartment of Industrial and Physical Pharmacy, Purdue University, West Lafayette, Indiana, USAen_US
dc.identifier.affiliationDrug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDivision of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, The University of North Carolina, Chapel Hill, North Carolina, USAen_US
dc.identifier.affiliationAustralian Commission on Safety and Quality in Health Care, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationMicrobiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute of Infection and Immunity, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationMonash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/29229637en_US
dc.identifier.doi10.1128/AAC.01790-17en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherHowden, Benjamin P
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptMicrobiology-
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