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Title: Q-Vax Q fever vaccine failures, Victoria, Australia 1994-2013
Austin Authors: Bond, Katherine A;Franklin, Lucinda J;Sutton, Brett;Firestone, Simon M
Affiliation: Communicable Disease Section, Health Protection Branch, Department of Health and Human Services, Melbourne, Victoria, Australia
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia
Asia-Pacific Centre for Animal Health, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Australia
Issue Date: 18-Dec-2017
Date: 2017-11-10
Publication information: Vaccine 2017; 35(51): 7084-7087
Abstract: Q-Vax®, a whole cell formalin inactivated vaccine, is currently the only licensed Q fever vaccine for humans world-wide. Efficacy is high, although vaccine failures have been described for those vaccinated within the incubation of a naturally acquired infection. In Australia, it is widely used to prevent occupational acquisition of Q fever and is the mainstay for outbreak control. A retrospective review of all notified cases of acute Q fever to the Victorian department of health, 1993–2013, revealed 34 of 659 cases were previously vaccinated and 10 cases were positive on pre-vaccination screening, precluding vaccination. Twenty-one cases described high-risk exposures for C. burnetii prior to and within 15 days post vaccination and are likely to have been vaccinated within the incubation period of a natural infection. Thirteen cases described symptom onset more than 15 days post vaccination and thus may represent the first described series of Q-Vax vaccine failures following appropriate vaccination.
DOI: 10.1016/j.vaccine.2017.10.088
Journal: Vaccine
PubMed URL:
Type: Journal Article
Subjects: Q fever
Coxiella burnetii
Vaccine failure
Appears in Collections:Journal articles

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