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Title: Survival outcomes in elderly men undergoing radical prostatectomy in Australia
Austin Authors: Ranasinghe, Weranja K B;Wang, Luke L;Persad, Rajendra A;Bolton, Damien M ;Lawrentschuk, Nathan;Sengupta, Shomik 
Affiliation: Urology Unit, Austin Health, Heidelberg, Victoria, Australia
Department of Urology, Eastern Health, Melbourne, Victoria, Australia
Department of Urology, NHS Trust, Bristol, UK
Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia
Department of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia
Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia
Issue Date: Mar-2018
Date: 2017-09-18
Publication information: ANZ Journal of Surgery 2018; 88(3): E189-E193
Abstract: BACKGROUND: To investigate the outcomes of patients older than 75 years of age in Victoria undergoing radical prostatectomy for prostate cancer. METHODS: Data on all men undergoing radical prostatectomy in Victoria between 1 January 2004 and 31 December 2014 were obtained from the Victorian Cancer Registry. Tumour characteristics including Gleason grade, stage of disease and cause of death were obtained. Statistical analysis was performed using chi-squared test, Cox proportional hazards method and Kaplan-Meier analysis. RESULTS: A total of 14 686 men underwent radical prostatectomy during the defined period, with a median follow-up of 58 months. Of these, 332 were men over the age of 75. All parameters are comparisons between patients >75 years of age and men <75 years of age. Men >75 years had a higher proportion of Gleason grade ≥8 disease (16.6% versus 11.4%, P < 0.001) but had similar stage of disease. Men >75 years had lower rates of 5- and 10-year overall survival (67.3% versus 96.3% and 27.7% versus 89.1%) and lower rates of 5- and 10-year prostate cancer-specific survival (96.2% versus 99.3% and 94.3% versus 97.4%), respectively. Age was an independent risk factor for prostate cancer specific and overall mortality on multivariate analysis (hazard ratio 1.49, 95% confidence interval 1.32-1.68; P < 0.001 and hazard ratio 4.26, 95% confidence interval 2.15-8.42; P < 0.001), when adjusted for stage and grade. CONCLUSION: Older men undergoing radical prostatectomy in Victoria had higher-grade disease but similar stage. Age was an independent risk factor for worse prostate cancer-specific and overall survival.
DOI: 10.1111/ans.14166
ORCID: 0000-0001-8553-5618
Journal: ANZ Journal of Surgery
PubMed URL: 28922686
PubMed URL:
Type: Journal Article
Subjects: Cancer
Appears in Collections:Journal articles

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