Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16893
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dc.contributor.authorRanasinghe, Weranja K B-
dc.contributor.authorWang, Luke L-
dc.contributor.authorPersad, Rajendra A-
dc.contributor.authorBolton, Damien M-
dc.contributor.authorLawrentschuk, Nathan-
dc.contributor.authorSengupta, Shomik-
dc.date2017-09-18-
dc.date.accessioned2017-10-04T22:31:12Z-
dc.date.available2017-10-04T22:31:12Z-
dc.date.issued2018-03-
dc.identifier.citationANZ Journal of Surgery 2018; 88(3): E189-E193en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16893-
dc.description.abstractBACKGROUND: To investigate the outcomes of patients older than 75 years of age in Victoria undergoing radical prostatectomy for prostate cancer. METHODS: Data on all men undergoing radical prostatectomy in Victoria between 1 January 2004 and 31 December 2014 were obtained from the Victorian Cancer Registry. Tumour characteristics including Gleason grade, stage of disease and cause of death were obtained. Statistical analysis was performed using chi-squared test, Cox proportional hazards method and Kaplan-Meier analysis. RESULTS: A total of 14 686 men underwent radical prostatectomy during the defined period, with a median follow-up of 58 months. Of these, 332 were men over the age of 75. All parameters are comparisons between patients >75 years of age and men <75 years of age. Men >75 years had a higher proportion of Gleason grade ≥8 disease (16.6% versus 11.4%, P < 0.001) but had similar stage of disease. Men >75 years had lower rates of 5- and 10-year overall survival (67.3% versus 96.3% and 27.7% versus 89.1%) and lower rates of 5- and 10-year prostate cancer-specific survival (96.2% versus 99.3% and 94.3% versus 97.4%), respectively. Age was an independent risk factor for prostate cancer specific and overall mortality on multivariate analysis (hazard ratio 1.49, 95% confidence interval 1.32-1.68; P < 0.001 and hazard ratio 4.26, 95% confidence interval 2.15-8.42; P < 0.001), when adjusted for stage and grade. CONCLUSION: Older men undergoing radical prostatectomy in Victoria had higher-grade disease but similar stage. Age was an independent risk factor for worse prostate cancer-specific and overall survival.en_US
dc.subjectCanceren_US
dc.subjectElderlyen_US
dc.subjectProstatectomyen_US
dc.subjectSurgeryen_US
dc.subjectUrologyen_US
dc.titleSurvival outcomes in elderly men undergoing radical prostatectomy in Australiaen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleANZ Journal of Surgeryen_US
dc.identifier.affiliationUrology Unit, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Urology, Eastern Health, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Urology, NHS Trust, Bristol, UKen_US
dc.identifier.affiliationDepartment of Surgery, The University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/en_US
dc.identifier.doi10.1111/ans.14166en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-8553-5618en_US
dc.identifier.orcid0000-0002-4006-0388en
dc.identifier.orcid0000-0002-5145-6783en
dc.identifier.orcid0000-0002-1276-9808en
dc.identifier.orcid0000-0003-3357-1216en
dc.identifier.pubmedid28922686-
dc.type.austinJournal Articleen_US
local.name.researcherBolton, Damien M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptUrology-
crisitem.author.deptUrology-
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