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Title: Mother's smoking and complex lung function of offspring in middle age: a cohort study from childhood
Austin Authors: Perret, Jennifer L ;Walters, Haydn;Johns, David;Gurrin, Lyle;Burgess, John;Lowe, Adrian;Thompson, Bruce R;Markos, James;Morrison, Stephen;Thomas, Paul;McDonald, Christine F ;Wood-Baker, Richard;Hopper, John L;Svanes, Cecilie;Giles, Graham G;Abramson, Michael J;Matheson, Melanie;Dharmage, Shyamali C
Affiliation: Department of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australia
Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia
Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, The University of Melbourne
'Breathe Well' Centre of Research Excellence for Chronic Respiratory Disease and Lung Ageing, School of Medicine, University of Tasmania, Hobart, Tasmania
School of Medicine, University of Notre Dame
Allergy, Immunology and Respiratory Medicine, The Alfred Hospital
Department of Medicine, Monash University
Launceston General Hospital, Launceston, Tasmania
Department of Medicine, University of Queensland, Brisbane, Queensland
Department of Medicine, University of New South Wales, Sydney, New South Wales, Australia
Department of Public Health, Seoul National University, Seoul, Korea
Centre for International Health, University of Bergen, Bergen, Norway
Cancer Epidemiology Centre, Cancer Council Victoria
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Issue Date: Jul-2016
Date: 2016-03-11
Publication information: Respirology 2016; 21(5): 911-919
Abstract: BACKGROUND AND OBJECTIVE: Existing evidence that supports maternal smoking to be a potential risk factor for chronic obstructive pulmonary disease (COPD) for adult offspring has barely been mentioned in major guideline documents, suggesting a need for more robust and consistent data. We aimed to examine whether such early life exposure can predispose to COPD in middle age, possibly through its interaction with personal smoking. METHODS: The fifth-decade follow-up of the Tasmanian Longitudinal Health Study cohort, which was first studied in 1968 (n = 8583), included a 2004 postal survey (n = 5729 responses) and subsequent laboratory attendance (n = 1389) for comprehensive lung function testing between 2006 and 2008. Multivariable linear and logistic regression models included sampling weights. RESULTS: Post-bronchodilator airflow obstruction (less than fifth percentile) was detected for 9.3% (n = 123) of middle-aged offspring. Its association with heavy maternal smoking (>20 cigarettes/day) during childhood was 2.7-fold higher than for those without exposure (95% confidence interval [1.3, 5.7] P = 0.009). Maternal smoking per se approximately doubled the adverse effect of personal smoking on gas transfer factor (z-score -0.46 [-0.6 to -0.3] vs -0.25 [-0.4 to -0.1], P[interaction] = 0.048) and was paradoxically associated with reduced residual volumes for non-smokers. CONCLUSIONS: Heavy maternal smoking during childhood appears to predispose to spirometrically defined COPD. The interplay between maternal and personal smoking on gas transfer factor suggests that early life exposure increases an individual's susceptibility to adult smoking exposure. These findings provide further evidence to suggest that maternal smoking might be a risk factor for COPD and reinforce the public health message advocating smoking abstinence.
DOI: 10.1111/resp.12750
Journal: Respirology
PubMed URL:
Type: Journal Article
Subjects: Adult offspring
Airflow obstruction
Gas transfer factor
Maternal smoking
Appears in Collections:Journal articles

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