Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPerret, Jennifer L-
dc.contributor.authorWalters, Haydn-
dc.contributor.authorJohns, David-
dc.contributor.authorGurrin, Lyle-
dc.contributor.authorBurgess, John-
dc.contributor.authorLowe, Adrian-
dc.contributor.authorThompson, Bruce R-
dc.contributor.authorMarkos, James-
dc.contributor.authorMorrison, Stephen-
dc.contributor.authorThomas, Paul-
dc.contributor.authorMcDonald, Christine F-
dc.contributor.authorWood-Baker, Richard-
dc.contributor.authorHopper, John L-
dc.contributor.authorSvanes, Cecilie-
dc.contributor.authorGiles, Graham G-
dc.contributor.authorAbramson, Michael J-
dc.contributor.authorMatheson, Melanie-
dc.contributor.authorDharmage, Shyamali C-
dc.identifier.citationRespirology 2016; 21(5): 911-919en_US
dc.description.abstractBACKGROUND AND OBJECTIVE: Existing evidence that supports maternal smoking to be a potential risk factor for chronic obstructive pulmonary disease (COPD) for adult offspring has barely been mentioned in major guideline documents, suggesting a need for more robust and consistent data. We aimed to examine whether such early life exposure can predispose to COPD in middle age, possibly through its interaction with personal smoking. METHODS: The fifth-decade follow-up of the Tasmanian Longitudinal Health Study cohort, which was first studied in 1968 (n = 8583), included a 2004 postal survey (n = 5729 responses) and subsequent laboratory attendance (n = 1389) for comprehensive lung function testing between 2006 and 2008. Multivariable linear and logistic regression models included sampling weights. RESULTS: Post-bronchodilator airflow obstruction (less than fifth percentile) was detected for 9.3% (n = 123) of middle-aged offspring. Its association with heavy maternal smoking (>20 cigarettes/day) during childhood was 2.7-fold higher than for those without exposure (95% confidence interval [1.3, 5.7] P = 0.009). Maternal smoking per se approximately doubled the adverse effect of personal smoking on gas transfer factor (z-score -0.46 [-0.6 to -0.3] vs -0.25 [-0.4 to -0.1], P[interaction] = 0.048) and was paradoxically associated with reduced residual volumes for non-smokers. CONCLUSIONS: Heavy maternal smoking during childhood appears to predispose to spirometrically defined COPD. The interplay between maternal and personal smoking on gas transfer factor suggests that early life exposure increases an individual's susceptibility to adult smoking exposure. These findings provide further evidence to suggest that maternal smoking might be a risk factor for COPD and reinforce the public health message advocating smoking abstinence.en_US
dc.subjectAdult offspringen_US
dc.subjectAirflow obstructionen_US
dc.subjectGas transfer factoren_US
dc.subjectMaternal smokingen_US
dc.titleMother's smoking and complex lung function of offspring in middle age: a cohort study from childhooden_US
dc.typeJournal Articleen_US
dc.identifier.affiliationDepartment of Respiratory and Sleep Medicine, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationInstitute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationAllergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, The University of Melbourneen_US
dc.identifier.affiliation'Breathe Well' Centre of Research Excellence for Chronic Respiratory Disease and Lung Ageing, School of Medicine, University of Tasmania, Hobart, Tasmaniaen_US
dc.identifier.affiliationSchool of Medicine, University of Notre Dameen_US
dc.identifier.affiliationAllergy, Immunology and Respiratory Medicine, The Alfred Hospitalen_US
dc.identifier.affiliationDepartment of Medicine, Monash Universityen_US
dc.identifier.affiliationLaunceston General Hospital, Launceston, Tasmaniaen_US
dc.identifier.affiliationDepartment of Medicine, University of Queensland, Brisbane, Queenslanden_US
dc.identifier.affiliationDepartment of Medicine, University of New South Wales, Sydney, New South Wales, Australiaen_US
dc.identifier.affiliationDepartment of Public Health, Seoul National University, Seoul, Koreaen_US
dc.identifier.affiliationCentre for International Health, University of Bergen, Bergen, Norwayen_US
dc.identifier.affiliationCancer Epidemiology Centre, Cancer Council Victoriaen_US
dc.identifier.affiliationDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australiaen_US
dc.type.austinJournal Articleen_US, Christine F
item.openairetypeJournal Article-
item.fulltextNo Fulltext- for Breathing and Sleep- for Breathing and Sleep- and Sleep Medicine-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

checked on Mar 4, 2024

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.