Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16786
Title: Rhenium and technetium-oxo complexes with thioamide derivatives of pyridylhydrazine bifunctional chelators conjugated to the tumour targeting peptides octreotate and cyclic-RGDfK
Austin Authors: North, Andrea J;Karas, John A;Ma, Michelle T;Blower, Philip J;Ackermann, Uwe ;White, Jonathan M;Donnelly, Paul S
Affiliation: The School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victorria, Australia
Division of Imaging Sciences and Biomedical Engineering, King’s College London, St Thomas’ Hospital, London, UK
Department of Molecular Imaging and Therapy, Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 21-Aug-2017
metadata.dc.date: 2017-08-02
Publication information: Inorganic Chemistry 2017; 56(16): 9725-9741
Abstract: This research aimed to develop new tumor targeted theranostic agents taking advantage of the similarities in coordination chemistry between technetium and rhenium. A γ-emitting radioactive isotope of technetium is commonly used in diagnostic imaging, and there are two β- emitting radioactive isotopes of rhenium that have the potential to be of use in radiotherapy. Variants of the 6-hydrazinonicotinamide (HYNIC) bifunctional ligands have been prepared by appending thioamide functional groups to 6-hydrazinonicotinamide to form pyridylthiosemicarbazide ligands (SHYNIC). The new bidentate ligands were conjugated to the tumor targeting peptides Tyr3-octreotate and cyclic-RGD. The new ligands and conjugates were used to prepare well-defined {M═O}3+ complexes (where M = 99mTc or natRe or 188Re) that feature two targeting peptides attached to the single metal ion. These new SHYNIC ligands are capable of forming well-defined rhenium and technetium complexes and offer the possibility of using the 99mTc imaging and 188/186Re therapeutic matched pairs.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16786
DOI: 10.1021/acs.inorgchem.7b01247
ORCID: 0000-0002-0707-6257
0000-0002-3349-7346
0000-0001-5373-0080
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/28766938
Type: Journal Article
Appears in Collections:Journal articles

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