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dc.contributor.authorNorth, Andrea J-
dc.contributor.authorKaras, John A-
dc.contributor.authorMa, Michelle T-
dc.contributor.authorBlower, Philip J-
dc.contributor.authorAckermann, Uwe-
dc.contributor.authorWhite, Jonathan M-
dc.contributor.authorDonnelly, Paul S-
dc.identifier.citationInorganic Chemistry 2017; 56(16): 9725-9741en_US
dc.description.abstractThis research aimed to develop new tumor targeted theranostic agents taking advantage of the similarities in coordination chemistry between technetium and rhenium. A γ-emitting radioactive isotope of technetium is commonly used in diagnostic imaging, and there are two β- emitting radioactive isotopes of rhenium that have the potential to be of use in radiotherapy. Variants of the 6-hydrazinonicotinamide (HYNIC) bifunctional ligands have been prepared by appending thioamide functional groups to 6-hydrazinonicotinamide to form pyridylthiosemicarbazide ligands (SHYNIC). The new bidentate ligands were conjugated to the tumor targeting peptides Tyr3-octreotate and cyclic-RGD. The new ligands and conjugates were used to prepare well-defined {M═O}3+ complexes (where M = 99mTc or natRe or 188Re) that feature two targeting peptides attached to the single metal ion. These new SHYNIC ligands are capable of forming well-defined rhenium and technetium complexes and offer the possibility of using the 99mTc imaging and 188/186Re therapeutic matched pairs.en_US
dc.titleRhenium and technetium-oxo complexes with thioamide derivatives of pyridylhydrazine bifunctional chelators conjugated to the tumour targeting peptides octreotate and cyclic-RGDfKen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleInorganic Chemistryen_US
dc.identifier.affiliationThe School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victorria, Australiaen_US
dc.identifier.affiliationDivision of Imaging Sciences and Biomedical Engineering, King’s College London, St Thomas’ Hospital, London, UKen_US
dc.identifier.affiliationDepartment of Molecular Imaging and Therapy, Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.type.austinJournal Articleen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article- Imaging and Therapy-
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