Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16751
Title: The effects on coagulation of the reinfusion of unprocessed residual blood from the cardiopulmonary bypass
Austin Authors: Iyer, Yolande-Leigh;Hayward, Philip A R;McNicol, Larry;Weinberg, Laurence 
Affiliation: Department of Cardiac Surgery, Austin Health, Heidelberg, Victoria, Australia
Department of Surgery, University of Melbourne, Parkville, Victoria, Australia
Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia
Department of Surgery and Centre for Anaesthesia, Perioperative and Pain Medicine, University of Melbourne, Parkville, Victoria, Australia
Issue Date: 3-Feb-2016
metadata.dc.date: 2016-02-03
Publication information: BMC Research Notes 2016; 9: 61
Abstract: BACKGROUND: Autologous blood transfusion is a common technique in cardiac surgery to directly re-infuse residual blood from the cardiopulmonary bypass (CPB) circuit to the patient. The objective of this study was to evaluate the effects of reinfusion of unprocessed residual pump blood on the coagulation system after separation from the CPB circuit and reversal of systemic heparin with protamine. MEASUREMENTS AND MAIN RESULTS: After ethics approval, 40 participants undergoing cardiac surgery were recruited in a prospective single center cohort study. Changes in coagulation were assessed with standard plasma based laboratory assays and thromboelastography. After the reinfusion of unprocessed residual pump blood there were decreases in the mean aPTT (effect size 6 s; SD: 6.05; p < 0.0001) and thrombin time (effect size 4.08 s; SD: 9.7; p = 0.01). There were no significant changes in PT, INR and D-dimer. Post reinfusion there were increases in fibrinogen, hemoglobin and platelet counts. There were improvements in the R-time (effect size 9.1 s; SD: 16.9; p = 0.0023), K-time (effect size 1.5 s; SD: 3.6 s; p = 0.0017), alpha angle (6.9°; SD: 15.8; p = 0.012), and maximum amplitude (3.0 mm; SD: 5.6, p = 0.002) on thromboelastography. CONCLUSION: The reinfusion of unprocessed residual CPB blood resulted in no deleterious effects on the coagulation system measured by both the common laboratory plasma based measurements of coagulation and thromboelastography.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16751
DOI: 10.1186/s13104-016-1868-y
ORCID: 0000-0001-7403-7680
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/26843072
Type: Journal Article
Subjects: Blood Coagulation
Blood Transfusion
Cardiopulmonary Bypass
Appears in Collections:Journal articles

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