Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16751
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dc.contributor.authorIyer, Yolande-Leigh-
dc.contributor.authorHayward, Philip A R-
dc.contributor.authorMcNicol, Larry-
dc.contributor.authorWeinberg, Laurence-
dc.date2016-02-03-
dc.date.accessioned2017-08-02T05:23:16Z-
dc.date.available2017-08-02T05:23:16Z-
dc.date.issued2016-02-03-
dc.identifier.citationBMC Research Notes 2016; 9: 61en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16751-
dc.description.abstractBACKGROUND: Autologous blood transfusion is a common technique in cardiac surgery to directly re-infuse residual blood from the cardiopulmonary bypass (CPB) circuit to the patient. The objective of this study was to evaluate the effects of reinfusion of unprocessed residual pump blood on the coagulation system after separation from the CPB circuit and reversal of systemic heparin with protamine. MEASUREMENTS AND MAIN RESULTS: After ethics approval, 40 participants undergoing cardiac surgery were recruited in a prospective single center cohort study. Changes in coagulation were assessed with standard plasma based laboratory assays and thromboelastography. After the reinfusion of unprocessed residual pump blood there were decreases in the mean aPTT (effect size 6 s; SD: 6.05; p < 0.0001) and thrombin time (effect size 4.08 s; SD: 9.7; p = 0.01). There were no significant changes in PT, INR and D-dimer. Post reinfusion there were increases in fibrinogen, hemoglobin and platelet counts. There were improvements in the R-time (effect size 9.1 s; SD: 16.9; p = 0.0023), K-time (effect size 1.5 s; SD: 3.6 s; p = 0.0017), alpha angle (6.9°; SD: 15.8; p = 0.012), and maximum amplitude (3.0 mm; SD: 5.6, p = 0.002) on thromboelastography. CONCLUSION: The reinfusion of unprocessed residual CPB blood resulted in no deleterious effects on the coagulation system measured by both the common laboratory plasma based measurements of coagulation and thromboelastography.en_US
dc.subjectBlood Coagulationen_US
dc.subjectBlood Transfusionen_US
dc.subjectCardiopulmonary Bypassen_US
dc.titleThe effects on coagulation of the reinfusion of unprocessed residual blood from the cardiopulmonary bypassen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBMC Research Notesen_US
dc.identifier.affiliationDepartment of Cardiac Surgery, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Surgery, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anaesthesia, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Surgery and Centre for Anaesthesia, Perioperative and Pain Medicine, University of Melbourne, Parkville, Victoria, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/26843072en_US
dc.identifier.doi10.1186/s13104-016-1868-yen_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-7403-7680en_US
dc.type.austinJournal Articleen_US
local.name.researcherWeinberg, Laurence
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptAnaesthesia-
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