Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16613
Title: Apneic oxygenation versus low-tidal-volume ventilation in anesthetized cardiac surgical patients: a prospective, single-center, randomized controlled trial
Authors: Machan, Laura
Churilov, Leonid
Hu, Raymond
Peyton, Philip J
Tan, Chong
Pillai, Parameswan
Ellard, Louise
Harley, Ian
Story, David A
Hayward, Philip AR
Matalanis, George
Roubos, Nicholas
Seevanayagam, Sivendran
Weinberg, Laurence
Date of Publication: 30-Dec-2016
Citation: Journal of Cardiothoracic and Vascular Anesthesia 2016; online first: 30 December
Abstract: OBJECTIVES: To compare the physiology of apneic oxygenation with low-tidal-volume (VT) ventilation during harvesting of the left internal mammary artery. DESIGN: Prospective, single-center, randomized trial. SETTING: Single-center teaching hospital. PARTICIPANTS: The study comprised 24 patients who underwent elective coronary artery bypass grafting surgery. INTERVENTIONS: Apneic oxygenation (apneic group: 12 participants) and low-VT ventilation (low-VT group: 12 participants) (2.5 mL/kg ideal body weight) for 15 minutes during harvesting of the left internal mammary artery. MEASUREMENT AND MAIN RESULTS: The primary endpoint was an absolute change in partial pressure of arterial carbon dioxide (PaCO2). Secondary endpoints were changes in arterial pH, pulmonary artery pressures (PAP), cardiac index, and pulmonary artery acceleration time and ease of surgical access. The mean (standard deviation) absolute increase in PaCO2 was 31.8 mmHg (7.6) in the apneic group and 17.6 mmHg (8.2) in the low-VT group (baseline-adjusted difference 14.2 mmHg [95% confidence interval 21.0-7.3], p<0.001). The mean (standard deviation) absolute decrease in pH was 0.15 (0.03) in the apneic group and 0.09 (0.03) in the low-VT group baseline-adjusted difference 0.06 [95% confidence interval 0.03-0.09], p<0.001. Differences in the rate of change over time between groups (time-by-treatment interaction) were observed for PaCO2 (p<0.001), pH (p<0.001), systolic PAP (p = 0.002), diastolic PAP (p = 0.023), and mean PAP (p = 0.034). Both techniques provided adequate ease of surgical access; however, apneic oxygenation was preferred predominantly. CONCLUSIONS: Apneic oxygenation caused a greater degree of hypercarbia and respiratory acidemia compared with low-VT ventilation. Neither technique had deleterious effects on PAP or cardiac function. Both techniques provided adequate ease of surgical access.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16613
DOI: 10.1053/j.jvca.2016.12.019
ORCID: 0000-0002-6479-1310
0000-0001-7403-7680
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/28284927
Type: Journal Article
Subject: Apneic oxygenation
Cardiac function
Cardiac surgery
Hypercarbia
Low-tidal-volume ventilation
Pulmonary artery pressures
Respiratory acidemia
Appears in Collections:Journal articles

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