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Title: Higher maternal serum prolactin levels are associated with reduced glucose tolerance during pregnancy
Austin Authors: Ekinci, Elif I ;Torkamani, Niloufar ;Ramchand, Sabashini K ;Churilov, Leonid ;Sikaris, Ken A;Lu, Zhong X;Houlihan, Christine A 
Affiliation: Department of Endocrinology, Austin Health, Heidelberg, Victoria, Australia
Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia
Menzies School of Health Research, Darwin, Northern Territory, Australia
Department of Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
Department of Chemical Pathology, Melbourne Pathology, Melbourne, Victoria, Australia
Department of Medicine, Monash University, Melbourne, Victoria, Australia
Mercy Hospital for Women, Heidelberg, Victoria, Australia
Issue Date: Sep-2017 2017-01-27
Publication information: Journal of Diabetes Investigation 2017; 8(5): 697-700
Abstract: It is unknown if high prolactin levels during pregnancy contribute to the development of gestational diabetes. We hypothesized that higher prolactin levels are associated with reduced glucose tolerance, as determined by higher 2-hour glucose level from an oral glucose tolerance test (OGTT) in pregnancy. 75 gram OGTT was performed at 28 weeks of gestation in 69 participants. A multiple regression analysis was used to determine the relationship between serum prolactin and 2-hour glucose levels. Multivariable regression analysis demonstrated an independent and significant relationship between third trimester prolactin and 2-hour glucose levels post OGTT. Higher prolactin levels were associated with higher glucose levels independent of age, BMI, gravidity and parity. Higher prolactin levels associated with reduced glucose tolerance in the third trimester of pregnancy suggests possible independent role of prolactin in the pathogenesis of gestational diabetes.
DOI: 10.1111/jdi.12634
ORCID: 0000-0003-2372-395X
PubMed URL:
Type: Journal Article
Subjects: Gestational Diabetes Mellitus
Maternal Glycaemia
Appears in Collections:Journal articles

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