Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/16604
Title: Higher maternal serum prolactin levels are associated with reduced glucose tolerance during pregnancy
Authors: Ekinci, Elif I
Torkamani, Niloufar
Ramchand, Sabashini K
Churilov, Leonid
Sikaris, Ken A
Lu, Zhong X
Houlihan, Christine A
Date of Publication: 27-Jan-2017
Citation: Journal of Diabetes Investigation 2017; online first: 27 January
Abstract: It is unknown if high prolactin levels during pregnancy contribute to the development of gestational diabetes. We hypothesized that higher prolactin levels are associated with reduced glucose tolerance, as determined by higher 2-hour glucose level from an oral glucose tolerance test (OGTT) in pregnancy. 75 gram OGTT was performed at 28 weeks of gestation in 69 participants. A multiple regression analysis was used to determine the relationship between serum prolactin and 2-hour glucose levels. Multivariable regression analysis demonstrated an independent and significant relationship between third trimester prolactin and 2-hour glucose levels post OGTT. Higher prolactin levels were associated with higher glucose levels independent of age, BMI, gravidity and parity. Higher prolactin levels associated with reduced glucose tolerance in the third trimester of pregnancy suggests possible independent role of prolactin in the pathogenesis of gestational diabetes.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16604
DOI: 10.1111/jdi.12634
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/28129477
Type: Journal Article
Subject: Gestational Diabetes Mellitus
Maternal Glycaemia
Pregnancy
Appears in Collections:Journal articles

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