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Title: Self-reported confusion is related to global and regional β-amyloid: data from the Women's healthy ageing project
Austin Authors: McCluskey, Georgia E;Yates, Paul A ;Villemagne, Victor L ;Rowe, Christopher C ;Szoeke, Cassandra EI
Affiliation: Centre for Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
Department of Medicine, University of Melbourne, Parkville, Victoria, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia
Institute for Health and Ageing, Melbourne, Victoria, Australia
Issue Date: Feb-2018
Date: 2017-01-20
Publication information: Brain Imaging and Behavior 2018; 12(1): 78-86
Abstract: Disease-modifying treatments for Alzheimer's disease (AD) may require implementation during early stages of β-amyloid accumulation, well before patients have objective cognitive decline. In this study we aimed to assess the clinical value of subjective cognitive impairment (SCI) by examining the cross-sectional relationship between β-amyloid load and SCI. Cerebral β-amyloid and SCI was assessed in a cohort of 112 cognitively normal subjects. Subjective cognition was evaluated using specific questions on memory and cognition and the MAC-Q. Participants had cerebral β-amyloid load measured with 18F-Florbetaben Positron Emission Tomography (PET). No associations were found between measures of subjective memory impairment and cerebral β-amyloid. However, by self-reported confusion was predictive of a higher global β-amyloid burden (p = 0.002), after controlling for confounders. Regional analysis revealed significant associations of confusion with β-amyloid in the prefrontal region (p = 0.004), posterior cingulate and precuneus cortices (p = 0.004) and the lateral temporal lobes (p = 0.001) after controlling for confounders. An in vivo biomarker for AD pathology was associated with SCI by self-reported confusion on cross-sectional analysis. Whilst there has been a large body of research on SMC, our results indicate more research is needed to explore symptoms of confusion.
DOI: 10.1007/s11682-016-9668-5
ORCID: 0000-0003-3910-2453
Journal: Brain Imaging and Behavior
PubMed URL:
Type: Journal Article
Subjects: Alzheimer’s disease
PET imaging
Subjective cognitive impairment
Subjective memory
Appears in Collections:Journal articles

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