Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16559
Title: Sepsis and siderosis, Yersinia enterocolitica and hereditary haemochromatosis
Austin Authors: Thwaites, Phoebe A ;Woods, Marion L
Affiliation: Victorian Liver Transplant Unit, Austin Health, Heidelberg, Victoria, Australia
Royal Brisbane and Women's Hospital, Herston, Queensland, Australia
Issue Date: 4-Jan-2017
metadata.dc.date: 2017-01-04
Publication information: BMJ Case Reports 2017; 2017: bcr-2016-218185
Abstract: A 60-year-old woman was admitted with sepsis, relative bradycardia, CT evidence of numerous small liver abscesses and 'skin bronzing' consistent with hereditary haemochromatosis (HH). Yersinia enterocolitica O:9 infection was confirmed by serology specimens taken 10 days apart. Iron overload was detected, and homozygous C282Y gene mutation confirmed HH. Liver biopsy revealed grade IV siderosis with micronodular cirrhosis. Haemochromatosis is a common, inherited disorder leading to iron overload that can produce end-organ damage from excess iron deposition. Haemochromatosis diagnosis allowed aggressive medical management with phlebotomy achieving normalisation of iron stores. Screening for complications of cirrhosis was started that included hepatoma surveillance. Iron overload states are known to increase patient susceptibility to infections caused by lower virulence bacteria lacking sophisticated iron metabolism pathways, for example, Yersinia enterocolitica Although these serious disseminated infections are rare, they may serve as markers for occult iron overload and should prompt haemochromatosis screening.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16559
DOI: 10.1136/bcr-2016-218185
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/28052950
Type: Journal Article
Type of Clinical Study or Trial: Case Series and Case Reports
Appears in Collections:Journal articles

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