Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16559
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dc.contributor.authorThwaites, Phoebe A-
dc.contributor.authorWoods, Marion L-
dc.date2017-01-04-
dc.date.accessioned2017-01-31T01:13:14Z-
dc.date.available2017-01-31T01:13:14Z-
dc.date.issued2017-01-04-
dc.identifier.citationBMJ Case Reports 2017; 2017: bcr-2016-218185en_US
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/16559-
dc.description.abstractA 60-year-old woman was admitted with sepsis, relative bradycardia, CT evidence of numerous small liver abscesses and 'skin bronzing' consistent with hereditary haemochromatosis (HH). Yersinia enterocolitica O:9 infection was confirmed by serology specimens taken 10 days apart. Iron overload was detected, and homozygous C282Y gene mutation confirmed HH. Liver biopsy revealed grade IV siderosis with micronodular cirrhosis. Haemochromatosis is a common, inherited disorder leading to iron overload that can produce end-organ damage from excess iron deposition. Haemochromatosis diagnosis allowed aggressive medical management with phlebotomy achieving normalisation of iron stores. Screening for complications of cirrhosis was started that included hepatoma surveillance. Iron overload states are known to increase patient susceptibility to infections caused by lower virulence bacteria lacking sophisticated iron metabolism pathways, for example, Yersinia enterocolitica Although these serious disseminated infections are rare, they may serve as markers for occult iron overload and should prompt haemochromatosis screening.en_US
dc.titleSepsis and siderosis, Yersinia enterocolitica and hereditary haemochromatosisen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleBMJ Case Reportsen_US
dc.identifier.affiliationVictorian Liver Transplant Unit, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationRoyal Brisbane and Women's Hospital, Herston, Queensland, Australiaen_US
dc.type.studyortrialCase Series and Case Reportsen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28052950en_US
dc.identifier.doi10.1136/bcr-2016-218185en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptGastroenterology and Hepatology-
crisitem.author.deptVictorian Liver Transplant Unit-
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