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Title: The association between unwanted sexual experiences and early-onset cervical cancer and precancer by age 25: a case-control study
Austin Authors: Jayasinghe, Yasmin L;Sasongko, Victoria;Lim, Rachel W;Grover, Sonia R ;Tabrizi, Sepehr N;Moore, Elya E;Donath, Susan;Garland, Suzanne M
Institutional Author: Early-onset Cervical Cancer (EOCC) study group
Affiliation: Department of Obstetrics and Gynaecology, Royal Women's Hospital, University of Melbourne, Melbourne, Victoria, Australia
Department of Gynaecology, Royal Children's Hospital, Melbourne, Victoria, Australia
Department of Medicine, Department of Medicine, Austin Health , Heidelberg, Victoria, Australia
Department of Internal Medicine, Singapore General Hospital, Singapore, Singapore
Murdoch Childrens Research Institute, Melbourne, Victoria, Australia
Women's Centre for Infectious Diseases, Royal Women's Hospital, Melbourne, Victoria, Australia
Clinical Epidemiology & Biostatistics Unit, Royal Children's Hospital, Melbourne, Victoria, Australia
Issue Date: 17-Nov-2016 2016-11-17
Publication information: Journal of Women's Health 2016; online first: 17 November
Abstract: BACKGROUND: We examined the association between unwanted sexual experiences and cervical cancer, cervical intraepithelial neoplasia 3, adenocarcinoma in situ, diagnosed ≤25 years of age. METHODS: A case-control study of women ≤55 years who attended gynecological hospitals in Australia between 1983 and 2007. Cases were ≤25 years when diagnosed with disease, control group 1 were "older women" >25 years at diagnosis; control group 2 were "well women" ≤25 years attending preventive health clinics. A self-administered postal survey was utilized. The main outcome measures were prevalence of childhood sexual abuse (<16 years) and unwanted adolescent sexual experiences (between 16 and 18 years) in cases compared to controls. RESULTS: Of 400 contactable subjects, 251 participated (62.8%). Prevalence of childhood sexual abuse in cases (26.6% [25/94]) was similar to other groups. Prevalence of childhood genital contact abuse in cases with cervical cancer was 45.5% [5/11], compared to older women (20% [10/50], p = 0.08) and well women (13.8% [8/58], p = 0.01), and was marginally more common compared to well women when adjusted for other lifestyle factors (odds ratio [OR]: 4.7 [1.0-22.6], p = 0.05). Prevalence of unwanted adolescent sexual experiences in cases was 28.9% [33/114]. Prevalence of adolescent penile-genital contact experiences in cervical cancer cases was 46.7% [7/15], compared to older women (9.4%, [6/64], p < 0.001) and well women (13.7%, [10/73], p = 0.003), and was more common compared to well women when adjusted for lifestyle (OR: 5.9 [1.4-24.9], p = 0.02) and sexual health risk factors (OR: 5.6 [1.4-22.1] p = 0.01). CONCLUSIONS: Unwanted sexual experiences with genital contact were a risk factor for invasive cervical cancer ≤25 years, likely due to a complex interplay of biological and environmental factors.
DOI: 10.1089/jwh.2016.5742
PubMed URL:
Type: Journal Article
Subjects: Cervical cancer
Human papillomavirus
Sexual abuse
Young women
Appears in Collections:Journal articles

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