Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16492
Title: Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia
Austin Authors: van Hal, Sebastiaan J;Espedido, Björn A;Coombs, Geoffrey W;Howden, Benjamin P ;Korman, Tony M;Nimmo, Graeme R;Gosbell, Iain B;Jensen, Slade O
Affiliation: School of Medicine, Western Sydney University, Sydney, NSW, Australia
Royal Prince Alfred Hospital, Sydney, NSW, Australia
Antimicrobial Resistance and Mobile Elements Group, Ingham Institute for Applied Medical Research, Sydney, NSW, Australia
School of Veterinary and Life Sciences, Murdoch University, Perth, Western Australia, Australia
PathWest Laboratory Medicine, Fiona Stanley Hospital, Perth, Western Australia, Australia
Austin Health, Heidelberg, Victoria, Australia
Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia
Monash Hospital, Melbourne, Victoria, Australia
Pathology Queensland, Brisbane, Queensland, Australia
Sydney South Western Pathology Service, NSW Pathology, Sydney, NSW, Australia
Issue Date: 1-Apr-2017
metadata.dc.date: 2016-12-28
Publication information: Journal of Antimicrobial Chemotherapy 2017; 72(4): 998-1001
Abstract: Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associated with the dissemination of a single ‘dominant’ ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.
URI: http://ahro.austin.org.au/austinjspui/handle/1/16492
DOI: 10.1093/jac/dkw539
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/28031272
Type: Journal Article
Appears in Collections:Journal articles

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