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https://ahro.austin.org.au/austinjspui/handle/1/16492| Title: | Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia | Austin Authors: | van Hal, Sebastiaan J;Espedido, Björn A;Coombs, Geoffrey W;Howden, Benjamin P ;Korman, Tony M;Nimmo, Graeme R;Gosbell, Iain B;Jensen, Slade O | Affiliation: | School of Medicine, Western Sydney University, Sydney, NSW, Australia Royal Prince Alfred Hospital, Sydney, NSW, Australia Antimicrobial Resistance and Mobile Elements Group, Ingham Institute for Applied Medical Research, Sydney, NSW, Australia School of Veterinary and Life Sciences, Murdoch University, Perth, Western Australia, Australia PathWest Laboratory Medicine, Fiona Stanley Hospital, Perth, Western Australia, Australia Austin Health, Heidelberg, Victoria, Australia Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australia Monash Hospital, Melbourne, Victoria, Australia Pathology Queensland, Brisbane, Queensland, Australia Sydney South Western Pathology Service, NSW Pathology, Sydney, NSW, Australia |
Issue Date: | 1-Apr-2017 | Date: | 2016-12-28 | Publication information: | Journal of Antimicrobial Chemotherapy 2017; 72(4): 998-1001 | Abstract: | Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associated with the dissemination of a single ‘dominant’ ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/16492 | DOI: | 10.1093/jac/dkw539 | Journal: | Journal of Antimicrobial Chemotherapy | PubMed URL: | https://pubmed.ncbi.nlm.nih.gov/28031272 | Type: | Journal Article |
| Appears in Collections: | Journal articles |
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