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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16492
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dc.contributor.authorvan Hal, Sebastiaan J-
dc.contributor.authorEspedido, Björn A-
dc.contributor.authorCoombs, Geoffrey W-
dc.contributor.authorHowden, Benjamin P-
dc.contributor.authorKorman, Tony M-
dc.contributor.authorNimmo, Graeme R-
dc.contributor.authorGosbell, Iain B-
dc.contributor.authorJensen, Slade O-
dc.date2016-12-28-
dc.date.accessioned2017-01-11T03:12:29Z-
dc.date.available2017-01-11T03:12:29Z-
dc.date.issued2017-04-01-
dc.identifier.citationJournal of Antimicrobial Chemotherapy 2017; 72(4): 998-1001en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/16492-
dc.description.abstractObjectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Methods: The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Results: In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusions: The recent emergence of vanA VRE in Australia was polyclonal and not associated with the dissemination of a single ‘dominant’ ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.en_US
dc.titlePolyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australiaen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Antimicrobial Chemotherapyen_US
dc.identifier.affiliationSchool of Medicine, Western Sydney University, Sydney, NSW, Australiaen_US
dc.identifier.affiliationRoyal Prince Alfred Hospital, Sydney, NSW, Australiaen_US
dc.identifier.affiliationAntimicrobial Resistance and Mobile Elements Group, Ingham Institute for Applied Medical Research, Sydney, NSW, Australiaen_US
dc.identifier.affiliationSchool of Veterinary and Life Sciences, Murdoch University, Perth, Western Australia, Australiaen_US
dc.identifier.affiliationPathWest Laboratory Medicine, Fiona Stanley Hospital, Perth, Western Australia, Australiaen_US
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationMonash Hospital, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationPathology Queensland, Brisbane, Queensland, Australiaen_US
dc.identifier.affiliationSydney South Western Pathology Service, NSW Pathology, Sydney, NSW, Australiaen_US
dc.identifier.pubmedurihttps://pubmed.ncbi.nlm.nih.gov/28031272en_US
dc.identifier.doi10.1093/jac/dkw539en_US
dc.type.contentTexten_US
dc.type.austinJournal Articleen_US
local.name.researcherHowden, Benjamin P
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptMicrobiology-
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