Multidetector (64+) computed tomography angiography of the lower limb in symptomatic peripheral arterial disease: assessment of image quality and accuracy in a tertiary care setting

2016-10-07

Lim, Jeremy C

Ranatunga, Dinesh

Owen, Andrew R

Spelman, Timothy D

Galea, Michael

Chuen, Jason

Lim, Ruth P

Journal Article

10.1097/RCT.0000000000000494

The aim of this study was to evaluate image quality and accuracy of 64+ detector multidetector computed tomography angiography (MDCTA) for hemodynamically significant (≥50%) stenosis in patients with symptomatic peripheral arterial disease (PAD) using digital subtraction angiography as the reference standard. METHODS: This is a retrospective study of 29 patients with PAD (19 men, 10 women) who underwent lower limb MDCTA (64- or 80-detector) and digital subtraction angiography. Image quality and accuracy of MDCTA for hemodynamically significant stenosis were assessed in the infrarenal aorta and 15 lower extremity segments. RESULTS: Four hundred fifty-three segments were adequately visualized at both modalities. Multidetector CTA had 84.8% sensitivity, 87.7% specificity, and 86.3% accuracy for significant stenosis. Accuracy was decreased in the calf when compromising arterial wall calcifications were present versus absent (55.9% vs 82.4%, P < 0.0001). CONCLUSIONS: 64+ MDCTA is accurate in patients with symptomatic PAD. However, diagnostic accuracy in below-knee vessels remains relatively poorer. Alternative imaging modalities should be considered where below-knee disease is suspected.

link

Journal of Computer Assisted Tomography 2016; online first: 7 October

Journal of Computer Assisted Tomography