Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/16472
Title: Durable remission of both multicentric Castleman's disease and Kaposi's sarcoma with valganciclovir, rituximab and liposomal doxorubicin in an HHV-8-positive, HIV-negative patient
Austin Authors: Murphy, C;Hawkes, E ;Chionh, Fiona;Chong, Geoff
Affiliation: Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia
Olivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University, Heidelberg, Victoria, Australia
Issue Date: Feb-2017
Date: 2016-10-28
Publication information: Journal of Clinical Pharmacy and Therapeutics 2017; 42(1): 111-114
Abstract: WHAT IS KNOWN AND OBJECTIVE: Human herpesvirus-8 (HHV-8)-positive, HIV-negative multicentric Castleman's disease is a rare lymphoproliferative disorder with no standardized treatment. Concurrent Kaposi's sarcoma, another HHV-8-related disease, is uncommon in HIV-negative patients. The role of antiviral therapy and rituximab in HIV-negative patients is not well established. CASE DESCRIPTION: We report a case of a 5-year, durable remission of HHV-8-positive, HIV-negative comorbid multicentric Castleman's disease and Kaposi's sarcoma treated with long-term valganciclovir, following initial rituximab and liposomal doxorubicin. WHAT IS NEW AND CONCLUSION: Currently, there is no defined role for antiviral therapy in the treatment of HIV-negative HHV-8-positive multicentric Castleman's disease and Kaposi's sarcoma. Ganciclovir followed by indefinite, continuous valganciclovir is thought to have contributed significantly to the durable response in this case.
URI: https://ahro.austin.org.au/austinjspui/handle/1/16472
DOI: 10.1111/jcpt.12472
Journal: Journal of Clinical Pharmacy and Therapeutics
PubMed URL: https://pubmed.ncbi.nlm.nih.gov/27790727
Type: Journal Article
Subjects: Kaposi's sarcoma
Human herpesvirus-8
Multicentric Castleman's disease
Valganciclovir
Type of Clinical Study or Trial: Case Series and Case Reports
Appears in Collections:Journal articles

Show full item record

Page view(s)

16
checked on Apr 21, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.