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dc.contributor.authorMurphy, C-
dc.contributor.authorHawkes, E-
dc.contributor.authorChionh, Fiona-
dc.contributor.authorChong, Geoff-
dc.identifier.citationJournal of Clinical Pharmacy and Therapeutics 2017; 42(1): 111-114en_US
dc.description.abstractWHAT IS KNOWN AND OBJECTIVE: Human herpesvirus-8 (HHV-8)-positive, HIV-negative multicentric Castleman's disease is a rare lymphoproliferative disorder with no standardized treatment. Concurrent Kaposi's sarcoma, another HHV-8-related disease, is uncommon in HIV-negative patients. The role of antiviral therapy and rituximab in HIV-negative patients is not well established. CASE DESCRIPTION: We report a case of a 5-year, durable remission of HHV-8-positive, HIV-negative comorbid multicentric Castleman's disease and Kaposi's sarcoma treated with long-term valganciclovir, following initial rituximab and liposomal doxorubicin. WHAT IS NEW AND CONCLUSION: Currently, there is no defined role for antiviral therapy in the treatment of HIV-negative HHV-8-positive multicentric Castleman's disease and Kaposi's sarcoma. Ganciclovir followed by indefinite, continuous valganciclovir is thought to have contributed significantly to the durable response in this case.en_US
dc.subjectKaposi's sarcomaen_US
dc.subjectHuman herpesvirus-8en_US
dc.subjectMulticentric Castleman's diseaseen_US
dc.titleDurable remission of both multicentric Castleman's disease and Kaposi's sarcoma with valganciclovir, rituximab and liposomal doxorubicin in an HHV-8-positive, HIV-negative patienten_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJournal of Clinical Pharmacy and Therapeuticsen_US
dc.identifier.affiliationDepartment of Medical Oncology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationOlivia Newton-John Cancer Research Institute and School of Cancer Medicine, La Trobe University, Heidelberg, Victoria, Australiaen_US
dc.type.studyortrialCase Series and Case Reportsen_US
dc.type.austinJournal Articleen_US
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristype Haematology- Newton-John Cancer Wellness and Research Centre- Newton-John Cancer Research Institute-
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