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Title: Magnetic resonance imaging features of gemistocytic astrocytoma
Austin Authors: Simkin, Paul M;Yang, Natalie ;Tsui, Alpha;Kalnins, Renate M;Fitt, Greg;Gaillard, Frank
Affiliation: Department of Radiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Department of Radiology, Austin Health, Heidelberg, Victoria, Australia
Department of Anatomical Pathology, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Department of Anatomical Pathology, Austin Health, Heidelberg, Victoria, Australia
Issue Date: Dec-2016 2016-10-21
Publication information: Journal of Medical Imaging and Radiation Oncology 2016; 60(6): 733-740
Abstract: INTRODUCTION: Gemistocytic astrocytoma is the second most common subtype of World Health Organization grade 2 astrocytoma, but has a worse prognosis than other grade 2 lesions. We aim to describe the MR imaging features of histopathologically proven gemistocytic tumours. METHODS: Ethics approval was obtained from both institutions. Patient consent was not required for this retrospective study. We reviewed MR imaging findings of 16 consecutive cases of histopathologically proven gemistocytic astrocytoma and anaplastic astrocytoma with gemistocytic features. RESULTS: Average patient age was 48 years, with a 3:1 male to female ratio. Based on our series, the typical appearance of a gemistocytic astrocytoma is a large, heterogeneous mass most commonly supratentorial and lobar. Regions of cyst formation, partial signal suppression on FLAIR images and contrast enhancement are all common features. Additionally, contrary to previous literature that describes gemistocytic astrocytoma as a purely supratentorial lesion, we present two cases of gemistocytic astrocytoma involving the brainstem. CONCLUSIONS: The possibility of gemistocytic astrocytoma should be considered in patients presenting with large heterogeneous tumours that have regions of cyst formation, partial FLAIR suppression and contrast enhancement. This may be especially useful in reconciling a lesion with high-grade MR imaging features with low-grade histopathology. An infratentorial location does not preclude the diagnosis of gemistocytic astrocytoma.
DOI: 10.1111/1754-9485.12550
PubMed URL:
Type: Journal Article
Subjects: Astrocytoma
Brain neoplasms
Gemistocytic astrocytoma
Magnetic Resonance Imaging
Appears in Collections:Journal articles

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