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Title: β-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and men
Austin Authors: Holmes, Sophie E;Esterlis, Irina;Mazure, Carolyn M;Lim, Yen Ying;Ames, David;Rainey-Smith, Stephanie R;Martins, Ralph N;Salvado, Olivier;Dore, Vincent;Villemagne, Victor L ;Rowe, Christopher C ;Laws, Simon M;Masters, Colin L ;Maruff, Paul;Pietrzak, Robert H
Institutional Author: AIBL Research Group
Affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia
Academic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia
National Ageing Research Institute, Parkville, Victoria, Australia
Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Sir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australia
The Commonwealth Scientific and Industrial Research Organization, Canberra, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
School of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia
Cogstate Ltd., Melbourne, Victoria, Australia
U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USA
Issue Date: Dec-2016
Date: 2016-08-17
Publication information: American Journal of Geriatric Psychiatry 2016; 24(12): 1191-1195
Abstract: OBJECTIVE: To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. METHODS: Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. RESULTS: Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). CONCLUSION: Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.
DOI: 10.1016/j.jagp.2016.08.007
ORCID: 0000-0003-3910-2453
Journal: American Journal of Geriatric Psychiatry
PubMed URL:
Type: Journal Article
Subjects: APOE
Appears in Collections:Journal articles

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