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dc.contributor.authorHolmes, Sophie E-
dc.contributor.authorEsterlis, Irina-
dc.contributor.authorMazure, Carolyn M-
dc.contributor.authorLim, Yen Ying-
dc.contributor.authorAmes, David-
dc.contributor.authorRainey-Smith, Stephanie R-
dc.contributor.authorMartins, Ralph N-
dc.contributor.authorSalvado, Olivier-
dc.contributor.authorDore, Vincent-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorRowe, Christopher C-
dc.contributor.authorLaws, Simon M-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorMaruff, Paul-
dc.contributor.authorPietrzak, Robert H-
dc.identifier.citationAmerican Journal of Geriatric Psychiatry 2016; 24(12): 1191-1195en
dc.description.abstractOBJECTIVE: To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. METHODS: Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. RESULTS: Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). CONCLUSION: Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.en
dc.titleβ-Amyloid, APOE and BDNF genotype, and depressive and anxiety symptoms in cognitively normal older women and menen
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Geriatric Psychiatryen
dc.identifier.affiliationDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USAen
dc.identifier.affiliationThe Florey Institute, The University of Melbourne, Parkville, Victoria, Australiaen
dc.identifier.affiliationAcademic Unit for Psychiatry of Old Age, St. Vincent's Health, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australiaen
dc.identifier.affiliationNational Ageing Research Institute, Parkville, Victoria, Australiaen
dc.identifier.affiliationCentre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australiaen
dc.identifier.affiliationSir James McCusker Alzheimer's Disease Research Unit, Hollywood Private Hospital, Perth, Western Australia, Australiaen
dc.identifier.affiliationThe Commonwealth Scientific and Industrial Research Organization, Canberra, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationSchool of Biomedical Sciences, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australiaen
dc.identifier.affiliationCogstate Ltd., Melbourne, Victoria, Australiaen
dc.identifier.affiliationU.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, CT, USAen
dc.contributor.corpauthorAIBL Research Group-
dc.type.austinJournal Articleen_US, Colin L
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristype Imaging and Therapy- Imaging and Therapy- Florey Institute of Neuroscience and Mental Health-
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