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Title: Targeting the vasculature: anti-angiogenic agents for malignant mesothelioma
Austin Authors: Chia, Puey Ling ;Russell, Prudence A;Scott, Andrew M ;John, Thomas 
Affiliation: Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia
Olivia-Newton John Cancer Research Institute, Austin Health, Heidelberg, Victoria, Australia
Department of Anatomical Pathology, St Vincent's Hospital, the University of Melbourne, Fitzroy, Victoria, Australia
School of Cancer Medicine, La Trobe University, Victoria, Australia
Department of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australia
Faculty of Medicine, The University of Melbourne, Melbourne, Australia
Issue Date: 12-Oct-2016 2016-10-04
Publication information: Expert Review of Anticancer Therapy 2016; online first: 4 October
Abstract: Introduction: Malignant mesothelioma (MM) is an aggressive malignancy of the pleura and other serosal membranes originating from mesothelial cells that, despite decades of research, continues to have limited therapeutic options and is associated with a poor prognosis. Areas covered: MMs induce a strong inflammatory response that is also associated with neoangiogenesis and activation of proangiogenic factors. Given this, several anti-angiogenic agents have been trialled in a variety of malignancies including mesothelioma. Herein we summarise the role of angiogenesis in MM and the current available data targeting these pathways. Expert commentary: The addition of bevacizumab to cisplatin/pemetrexed chemotherapy is currently a therapeutic option with a proven 2.7 month overall survival benefit in fit patients less than 75. Other antiangiogenics such as nintedinib show early promise, although the Phase III trial results are eagerly awaited before this therapy enters treatment paradigms. Beyond this, it is likely that combinations of antiangiogenics with immunotherapies will be investigated in future studies.
DOI: 10.1080/14737140.2016.1244008
ORCID: 0000-0002-6656-295X
Journal: Expert Review of Anticancer Therapy
PubMed URL:
Type: Journal Article
Subjects: Angiogenesis
Anti-angiogenic agents
Tumour microenvironment
Vascular endothelial growth factor
Appears in Collections:Journal articles

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