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dc.contributor.authorChia, Puey Ling-
dc.contributor.authorRussell, Prudence A-
dc.contributor.authorScott, Andrew M-
dc.contributor.authorJohn, Thomas-
dc.identifier.citationExpert Review of Anticancer Therapy 2016; online first: 4 Octoberen_US
dc.description.abstractIntroduction: Malignant mesothelioma (MM) is an aggressive malignancy of the pleura and other serosal membranes originating from mesothelial cells that, despite decades of research, continues to have limited therapeutic options and is associated with a poor prognosis. Areas covered: MMs induce a strong inflammatory response that is also associated with neoangiogenesis and activation of proangiogenic factors. Given this, several anti-angiogenic agents have been trialled in a variety of malignancies including mesothelioma. Herein we summarise the role of angiogenesis in MM and the current available data targeting these pathways. Expert commentary: The addition of bevacizumab to cisplatin/pemetrexed chemotherapy is currently a therapeutic option with a proven 2.7 month overall survival benefit in fit patients less than 75. Other antiangiogenics such as nintedinib show early promise, although the Phase III trial results are eagerly awaited before this therapy enters treatment paradigms. Beyond this, it is likely that combinations of antiangiogenics with immunotherapies will be investigated in future studies.en_US
dc.subjectAnti-angiogenic agentsen_US
dc.subjectTumour microenvironmenten_US
dc.subjectVascular endothelial growth factoren_US
dc.titleTargeting the vasculature: anti-angiogenic agents for malignant mesotheliomaen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleExpert Review of Anticancer Therapyen_US
dc.identifier.affiliationDepartment of Medical Oncology, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationOlivia-Newton John Cancer Research Institute, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Anatomical Pathology, St Vincent's Hospital, the University of Melbourne, Fitzroy, Victoria, Australiaen_US
dc.identifier.affiliationSchool of Cancer Medicine, La Trobe University, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Molecular Imaging and Therapy, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationFaculty of Medicine, The University of Melbourne, Melbourne, Australiaen_US
dc.type.austinJournal Articleen_US
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Newton-John Cancer Research Institute- Imaging and Therapy- Newton-John Cancer Research Institute- Newton-John Cancer Research Institute- Oncology- Newton-John Cancer Wellness and Research Centre-
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