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Title: Use of bacterial whole-genome sequencing to understand and improve the management of invasive Staphylococcus aureus infections
Austin Authors: Giulieri, Stefano G ;Holmes, Natasha E ;Stinear, Timothy P;Howden, Benjamin P 
Affiliation: Austin Health, Heidelberg, Victoria, Australia
Microbiological Diagnostic Unit Public Health Laboratory, Melbourne, Victoria, Australia
Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia
Doherty Applied Microbial Genomics, Melbourne, Victoria, Australia
Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia
Issue Date: Nov-2017 2016-09-14
Publication information: Expert Review of Anti-infective Therapy 2017; 14(11): 1023-1036
Abstract: Introduction Management of invasive Staphylococcus aureus infections is complex. Dramatic improvements in bacterial whole genome sequencing (WGS) offer new opportunities for personalising the treatment of S. aureus infections. Areas covered: We address recent achievements in S. aureus genomics, describe genetic determinants of antibiotic resistance and summarise studies that have defined molecular characteristics associated with risk and outcome of S. aureus invasive infections. Potential clinical use of WGS for resistance prediction, infection outcome stratification and management of persistent /relapsing infections is critically discussed. Expert commentary: WGS is not only providing invaluable information to track the emergence and spread of important S. aureus clones, but also allows rapid determination of resistance genotypes in the clinical environment. An evolving opportunity is to infer clinically important outcomes and optimal therapeutic approaches from widely available S. aureus genome data, with the goal of individualizing management of invasive S. aureus infections.
DOI: 10.1080/14787210.2016.1233815
Journal: Expert Review of Anti-infective Therapy
PubMed URL:
Type: Journal Article
Subjects: Staphylococcus aureus
Whole genome sequencing
Appears in Collections:Journal articles

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