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dc.contributor.authorGiulieri, Stefano G-
dc.contributor.authorHolmes, Natasha E-
dc.contributor.authorStinear, Timothy P-
dc.contributor.authorHowden, Benjamin P-
dc.identifier.citationExpert Review of Anti-infective Therapy 2017; 14(11): 1023-1036en_US
dc.description.abstractIntroduction Management of invasive Staphylococcus aureus infections is complex. Dramatic improvements in bacterial whole genome sequencing (WGS) offer new opportunities for personalising the treatment of S. aureus infections. Areas covered: We address recent achievements in S. aureus genomics, describe genetic determinants of antibiotic resistance and summarise studies that have defined molecular characteristics associated with risk and outcome of S. aureus invasive infections. Potential clinical use of WGS for resistance prediction, infection outcome stratification and management of persistent /relapsing infections is critically discussed. Expert commentary: WGS is not only providing invaluable information to track the emergence and spread of important S. aureus clones, but also allows rapid determination of resistance genotypes in the clinical environment. An evolving opportunity is to infer clinically important outcomes and optimal therapeutic approaches from widely available S. aureus genome data, with the goal of individualizing management of invasive S. aureus infections.en_US
dc.subjectStaphylococcus aureusen_US
dc.subjectWhole genome sequencingen_US
dc.titleUse of bacterial whole-genome sequencing to understand and improve the management of invasive Staphylococcus aureus infectionsen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleExpert Review of Anti-infective Therapyen_US
dc.identifier.affiliationAustin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationMicrobiological Diagnostic Unit Public Health Laboratory, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationInfectious Diseases Department, Austin Health, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationDoherty Applied Microbial Genomics, Melbourne, Victoria, Australiaen_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australiaen_US
dc.type.austinJournal Articleen_US
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Diseases- Diseases- Analytics Research and Evaluation (DARE) Centre- Diseases-
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