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Title: Magnetic resonance imaging for prostate cancer: Comparative studies including radical prostatectomy specimens and template transperineal biopsy
Austin Authors: Toner, Liam ;Weerakoon, Mahesha;Bolton, Damien M ;Ryan, A;Katelaris, N;Lawrentschuk, Nathan
Affiliation: Department of Pathology, TissuPath Specialist Pathology Services
Austin Health, Heidelberg, Victoria, Australia
Issue Date: 3-Dec-2015
Date: 2015-10-19
Publication information: Prostate International 2015, vol. 3(4) p. 107-14
Abstract: PURPOSE: Multiparametric magnetic resonance imaging (mpMRI) is an emerging technique aiming to improve upon the diagnostic sensitivity of prostate biopsy. Because of variance in interpretation and application of techniques, results may vary. There is likely a learning curve to establish consistent reporting of mpMRI. This study aims to review current literature supporting the diagnostic utility of mpMRI when compared with radical prostatectomy (RP) and template transperineal biopsy (TTPB) specimens. METHODS: MEDLINE and PubMed database searches were conducted identifying relevant literature related to comparison of mpMRI with RP or TTPB histology. RESULTS: Data suggest that compared with RP and TTPB specimens, the sensitivity of mpMRI for prostate cancer (PCa) detection is 80-90% and the specificity for suspicious lesions is between 50% and 90%. CONCLUSIONS: mpMRI has an increasing role for PCa diagnosis, staging, and directing management toward improving patient outcomes. Its sensitivity and specificity when compared with RP and TTPB specimens are less than what some expect, possibly reflecting a learning curve for the technique of mpMRI.
DOI: 10.1016/j.prnil.2015.09.006
Journal: Prostate International
PubMed URL:
Type: Journal Article
Subjects: Histopathology
Magnetic Resonance Imaging
Prostatic neoplasms
Type of Clinical Study or Trial: Narrative Reviews
Appears in Collections:Journal articles

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