Please use this identifier to cite or link to this item:
Title: Cortical hyperexcitability in progressive myoclonus epilepsy: a study with transcranial magnetic stimulation.
Austin Authors: Reutens, David C;Puce, Aina;Berkovic, Samuel F 
Affiliation: Department of Neurology, Austin Hospital, Melbourne, Victoria, Australia
Issue Date: 1-Jan-1993
Publication information: Neurology; 43(1): 186-92
Abstract: In progressive myoclonus epilepsy (PME), responses to afferent input are frequently abnormal. It is unclear whether the abnormality lies at the cortical, subcortical, or segmental level. To obtain evidence for an exaggerated effect on motor cortical excitability, we used peripheral nerve and transcranial magnetic stimulation in controls and subjects with idiopathic generalized epilepsy and PME. Mean threshold intensity was higher in those with idiopathic generalized epilepsy and PME than in controls, probably as a result of anticonvulsant treatment. A long-latency response to peripheral stimulation and an exaggerated facilitatory effect of peripheral stimulation on the motor evoked potential was present in subjects with PME. Latency differences between the late responses in the upper and lower limbs provided evidence against a segmental reflex and implicated rapidly conducting fibers in the spinal cord. Both the late response and the facilitatory effect had onset latencies consistent with a transcortical pathway, suggesting an exaggerated effect of afferent input on motor cortical excitability in PME.
Gov't Doc #: 8423883
Type: Journal Article
Subjects: Adaptation, Physiological
Epilepsies, Myoclonic.physiopathology
Evoked Potentials, Somatosensory
Middle Aged
Motor Cortex.physiopathology
Physical Stimulation
Reaction Time.physiology
Transcranial Magnetic Stimulation
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Nov 25, 2022

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.