Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/13361
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dc.contributor.authorReutens, David Cen
dc.contributor.authorPuce, Ainaen
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-16T03:11:54Z
dc.date.available2015-05-16T03:11:54Z
dc.date.issued1993-01-01en
dc.identifier.citationNeurology; 43(1): 186-92en
dc.identifier.govdoc8423883en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/13361en
dc.description.abstractIn progressive myoclonus epilepsy (PME), responses to afferent input are frequently abnormal. It is unclear whether the abnormality lies at the cortical, subcortical, or segmental level. To obtain evidence for an exaggerated effect on motor cortical excitability, we used peripheral nerve and transcranial magnetic stimulation in controls and subjects with idiopathic generalized epilepsy and PME. Mean threshold intensity was higher in those with idiopathic generalized epilepsy and PME than in controls, probably as a result of anticonvulsant treatment. A long-latency response to peripheral stimulation and an exaggerated facilitatory effect of peripheral stimulation on the motor evoked potential was present in subjects with PME. Latency differences between the late responses in the upper and lower limbs provided evidence against a segmental reflex and implicated rapidly conducting fibers in the spinal cord. Both the late response and the facilitatory effect had onset latencies consistent with a transcortical pathway, suggesting an exaggerated effect of afferent input on motor cortical excitability in PME.en
dc.language.isoenen
dc.subject.otherAdaptation, Physiologicalen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherChilden
dc.subject.otherEpilepsies, Myoclonic.physiopathologyen
dc.subject.otherEvoked Potentials, Somatosensoryen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherMotor Cortex.physiopathologyen
dc.subject.otherPhysical Stimulationen
dc.subject.otherReaction Time.physiologyen
dc.subject.otherTranscranial Magnetic Stimulationen
dc.titleCortical hyperexcitability in progressive myoclonus epilepsy: a study with transcranial magnetic stimulation.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationDepartment of Neurology, Austin Hospital, Melbourne, Victoria, Australiaen
dc.description.pages186-92en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/8423883en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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