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Title: | Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception. | Austin Authors: | Young, N R;Baker, H W;Liu, G;Seeman, Ego | Affiliation: | University of Melbourne, Department of Endocrinology, Austin Hospital, Victoria, Australia | Issue Date: | 1-Oct-1993 | Publication information: | The Journal of Clinical Endocrinology and Metabolism; 77(4): 1028-32 | Abstract: | To determine the effect of androgens on body composition and muscle strength, we measured fat-free mass (kg), fat mass (kg), and bone density (g/cm2) by dual x-ray absorptiometry, and muscle strength (Newton meters) by dynamometry in a controlled, prospective study involving 13 nonathletic men receiving testosterone enanthate 200 mg/week in for 6 months and 8 healthy controls. Biochemical markers of bone turnover were measured in the treated subjects at baseline and 6 months. In the treated subjects at 6 months, fat-free mass (mean +/- SEM) increased by 9.6 +/- 1.0% (P < or = 0.01) whereas fat mass decreased by 16.2 +/- 6.7% (P < or = 0.05). Changes in muscle strength ranged from -1.6-19.2%. Only hip adduction increased 19.2 +/- 9.5% (P < 0.05). Changes in bone density ranged from -1.3-5.2%, decreasing significantly at one site and increasing significantly at four of the nine sites measured (P < 0.05). Serum testosterone increased by 91.1 +/- 7.5% (P < 0.01), and testicular volume decreased by 24.0 +/- 3.2% (P < 0.01). Serum osteocalcin increased by 35.7 +/- 17.3% (P < 0.05), serum immunoreactive PTH (iPTH) increased by 41.4 +/- 15.1% (P < 0.05), serum calcium decreased by 2.3 +/- 1.0% (P < 0.05), and serum albumin decreased by 4.5 +/- 1.7% (P < 0.05). There were no detectable changes in fat-free mass, fat mass, muscle strength, or bone density in controls. The administration of testosterone enanthate in pharmacological doses for 6 months resulted in a modest reduction in fat mass and small increases in fat-free mass, muscle strength, and bone density. These changes do not support the use of androgens for enhancing athletic performance. | Gov't Doc #: | 8408450 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/13355 | DOI: | 10.1210/jcem.77.4.8408450 | Journal: | The Journal of Clinical Endocrinology and Metabolism | URL: | https://pubmed.ncbi.nlm.nih.gov/8408450 | Type: | Journal Article | Subjects: | Androgens Biology Body Weight--changes Case Control Studies Contraception Contraceptive Agents Contraceptive Agents, Male Endocrine System Examinations And Diagnoses Family Planning Hematological Effects Hemic System Hormones Laboratory Examinations And Diagnoses Laboratory Procedures Physiology Prospective Studies Research Report Serum Calcium Level Serum Protein Effects Spermatogenesis Blocking Agents Studies Testosterone Absorptiometry, Photon Adult Alkaline Phosphatase.blood Biological Markers Body Composition.drug effects Bone Density.drug effects Calcium.blood Contraceptive Agents, Male.pharmacokinetics.pharmacology Creatinine.urine Humans Hydroxyproline.urine Male Muscles.drug effects.physiology Osteocalcin.blood Parathyroid Hormone.blood Phosphates.blood Regression Analysis Serum Albumin.analysis Testosterone.analogs & derivatives.blood.pharmacokinetics.pharmacology |
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