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https://ahro.austin.org.au/austinjspui/handle/1/13355
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Young, N R | en |
dc.contributor.author | Baker, H W | en |
dc.contributor.author | Liu, G | en |
dc.contributor.author | Seeman, Ego | en |
dc.date.accessioned | 2015-05-16T03:11:28Z | |
dc.date.available | 2015-05-16T03:11:28Z | |
dc.date.issued | 1993-10-01 | en |
dc.identifier.citation | The Journal of Clinical Endocrinology and Metabolism; 77(4): 1028-32 | en |
dc.identifier.govdoc | 8408450 | en |
dc.identifier.other | PUBMED | en |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/13355 | en |
dc.description.abstract | To determine the effect of androgens on body composition and muscle strength, we measured fat-free mass (kg), fat mass (kg), and bone density (g/cm2) by dual x-ray absorptiometry, and muscle strength (Newton meters) by dynamometry in a controlled, prospective study involving 13 nonathletic men receiving testosterone enanthate 200 mg/week in for 6 months and 8 healthy controls. Biochemical markers of bone turnover were measured in the treated subjects at baseline and 6 months. In the treated subjects at 6 months, fat-free mass (mean +/- SEM) increased by 9.6 +/- 1.0% (P < or = 0.01) whereas fat mass decreased by 16.2 +/- 6.7% (P < or = 0.05). Changes in muscle strength ranged from -1.6-19.2%. Only hip adduction increased 19.2 +/- 9.5% (P < 0.05). Changes in bone density ranged from -1.3-5.2%, decreasing significantly at one site and increasing significantly at four of the nine sites measured (P < 0.05). Serum testosterone increased by 91.1 +/- 7.5% (P < 0.01), and testicular volume decreased by 24.0 +/- 3.2% (P < 0.01). Serum osteocalcin increased by 35.7 +/- 17.3% (P < 0.05), serum immunoreactive PTH (iPTH) increased by 41.4 +/- 15.1% (P < 0.05), serum calcium decreased by 2.3 +/- 1.0% (P < 0.05), and serum albumin decreased by 4.5 +/- 1.7% (P < 0.05). There were no detectable changes in fat-free mass, fat mass, muscle strength, or bone density in controls. The administration of testosterone enanthate in pharmacological doses for 6 months resulted in a modest reduction in fat mass and small increases in fat-free mass, muscle strength, and bone density. These changes do not support the use of androgens for enhancing athletic performance. | en |
dc.language.iso | en | en |
dc.subject.other | Androgens | en |
dc.subject.other | Biology | en |
dc.subject.other | Body Weight--changes | en |
dc.subject.other | Case Control Studies | en |
dc.subject.other | Contraception | en |
dc.subject.other | Contraceptive Agents | en |
dc.subject.other | Contraceptive Agents, Male | en |
dc.subject.other | Endocrine System | en |
dc.subject.other | Examinations And Diagnoses | en |
dc.subject.other | Family Planning | en |
dc.subject.other | Hematological Effects | en |
dc.subject.other | Hemic System | en |
dc.subject.other | Hormones | en |
dc.subject.other | Laboratory Examinations And Diagnoses | en |
dc.subject.other | Laboratory Procedures | en |
dc.subject.other | Physiology | en |
dc.subject.other | Prospective Studies | en |
dc.subject.other | Research Report | en |
dc.subject.other | Serum Calcium Level | en |
dc.subject.other | Serum Protein Effects | en |
dc.subject.other | Spermatogenesis Blocking Agents | en |
dc.subject.other | Studies | en |
dc.subject.other | Testosterone | en |
dc.subject.other | Absorptiometry, Photon | en |
dc.subject.other | Adult | en |
dc.subject.other | Alkaline Phosphatase.blood | en |
dc.subject.other | Biological Markers | en |
dc.subject.other | Body Composition.drug effects | en |
dc.subject.other | Bone Density.drug effects | en |
dc.subject.other | Calcium.blood | en |
dc.subject.other | Contraceptive Agents, Male.pharmacokinetics.pharmacology | en |
dc.subject.other | Creatinine.urine | en |
dc.subject.other | Humans | en |
dc.subject.other | Hydroxyproline.urine | en |
dc.subject.other | Male | en |
dc.subject.other | Muscles.drug effects.physiology | en |
dc.subject.other | Osteocalcin.blood | en |
dc.subject.other | Parathyroid Hormone.blood | en |
dc.subject.other | Phosphates.blood | en |
dc.subject.other | Regression Analysis | en |
dc.subject.other | Serum Albumin.analysis | en |
dc.subject.other | Testosterone.analogs & derivatives.blood.pharmacokinetics.pharmacology | en |
dc.title | Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception. | en |
dc.type | Journal Article | en |
dc.identifier.journaltitle | The Journal of Clinical Endocrinology and Metabolism | en |
dc.identifier.affiliation | University of Melbourne, Department of Endocrinology, Austin Hospital, Victoria, Australia | en |
dc.identifier.doi | 10.1210/jcem.77.4.8408450 | en |
dc.description.pages | 1028-32 | en |
dc.relation.url | https://pubmed.ncbi.nlm.nih.gov/8408450 | en |
dc.type.austin | Journal Article | en |
local.name.researcher | Seeman, Ego | |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairetype | Journal Article | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Endocrinology | - |
Appears in Collections: | Journal articles |
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