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Title: Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception.
Austin Authors: Young, N R;Baker, H W;Liu, G;Seeman, Ego 
Affiliation: University of Melbourne, Department of Endocrinology, Austin Hospital, Victoria, Australia
Issue Date: 1-Oct-1993
Publication information: The Journal of Clinical Endocrinology and Metabolism; 77(4): 1028-32
Abstract: To determine the effect of androgens on body composition and muscle strength, we measured fat-free mass (kg), fat mass (kg), and bone density (g/cm2) by dual x-ray absorptiometry, and muscle strength (Newton meters) by dynamometry in a controlled, prospective study involving 13 nonathletic men receiving testosterone enanthate 200 mg/week in for 6 months and 8 healthy controls. Biochemical markers of bone turnover were measured in the treated subjects at baseline and 6 months. In the treated subjects at 6 months, fat-free mass (mean +/- SEM) increased by 9.6 +/- 1.0% (P < or = 0.01) whereas fat mass decreased by 16.2 +/- 6.7% (P < or = 0.05). Changes in muscle strength ranged from -1.6-19.2%. Only hip adduction increased 19.2 +/- 9.5% (P < 0.05). Changes in bone density ranged from -1.3-5.2%, decreasing significantly at one site and increasing significantly at four of the nine sites measured (P < 0.05). Serum testosterone increased by 91.1 +/- 7.5% (P < 0.01), and testicular volume decreased by 24.0 +/- 3.2% (P < 0.01). Serum osteocalcin increased by 35.7 +/- 17.3% (P < 0.05), serum immunoreactive PTH (iPTH) increased by 41.4 +/- 15.1% (P < 0.05), serum calcium decreased by 2.3 +/- 1.0% (P < 0.05), and serum albumin decreased by 4.5 +/- 1.7% (P < 0.05). There were no detectable changes in fat-free mass, fat mass, muscle strength, or bone density in controls. The administration of testosterone enanthate in pharmacological doses for 6 months resulted in a modest reduction in fat mass and small increases in fat-free mass, muscle strength, and bone density. These changes do not support the use of androgens for enhancing athletic performance.
Gov't Doc #: 8408450
DOI: 10.1210/jcem.77.4.8408450
Type: Journal Article
Subjects: Androgens
Body Weight--changes
Case Control Studies
Contraceptive Agents
Contraceptive Agents, Male
Endocrine System
Examinations And Diagnoses
Family Planning
Hematological Effects
Hemic System
Laboratory Examinations And Diagnoses
Laboratory Procedures
Prospective Studies
Research Report
Serum Calcium Level
Serum Protein Effects
Spermatogenesis Blocking Agents
Absorptiometry, Photon
Alkaline Phosphatase.blood
Biological Markers
Body Composition.drug effects
Bone Density.drug effects
Contraceptive Agents, Male.pharmacokinetics.pharmacology
Muscles.drug effects.physiology
Parathyroid Hormone.blood
Regression Analysis
Serum Albumin.analysis
Testosterone.analogs & derivatives.blood.pharmacokinetics.pharmacology
Appears in Collections:Journal articles

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