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Title: Neurotransmitters and neuropeptides in blood pressure regulation in the spontaneously hypertensive rat.
Austin Authors: Louis, William J ;Conway, Elizabeth L;Howes, L G;Maccarrone, C;Beart, P M;Jarrott, B
Affiliation: Department of Medicine and Clinical Pharmacology, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Aug-1987
Publication information: Canadian Journal of Physiology and Pharmacology; 65(8): 1633-7
Abstract: Studies of the roles played by neurotransmitters in the development of hypertension in the spontaneously hypertensive (SHR) rat are complicated by the presence of genetic differences between SHR and normotensive control rats, which are not related to differences in blood pressure. One approach that may be used in an attempt to overcome this difficulty is to study the manner in which neurotransmitter and metabolite levels change with age, and to relate these changes to alterations in blood pressure with ageing. Noradrenaline (NA) levels in the brainstem and spinal cord of SHR and Wistar Kyoto rats fell with age, while 3,4-dihydroxyphenylethyleneglycol (DHPG) levels (a neuronal metabolite of noradrenaline) remained constant. Similar changes were seen when NA and DHPG levels were measured in the discrete brainstem A1, A2, and C2 region, and when adrenaline, NA, and DHPG levels were examined in the C1 region. Differences in age-related changes of neuropeptide Y (NPY) levels were also found in the ventromedial nucleus of the hypothalamus and the locus coeruleus, and of beta-endorphin in the anterior hypothalamic nucleus, the paragigantocellular nucleus of the brainstem, and the locus coeruleus. These changes may indicate either a progressive increase in the activity of neurons in the sympathoexcitatory C1 region or a progressive reduction in the activity of vasodepressor A1, A2, and C2 regions with ageing, or both. However, changes in catecholamines and metabolites with age were similar in both strains and therefore cannot readily explain the more rapid rise in blood pressure with ageing in SHR rats.
Gov't Doc #: 2961419
Journal: Canadian journal of physiology and pharmacology
Type: Journal Article
Subjects: Aging
Blood Pressure
Brain.growth & development
Brain Stem.growth & development
Hypothalamus.growth & development
Neuropeptide Y.metabolism
Rats, Inbred SHR.growth & development
Rats, Inbred Strains.growth & development
Rats, Inbred WKY.growth & development
Reference Values
Appears in Collections:Journal articles

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