Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12903
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dc.contributor.authorLouis, William Jen
dc.contributor.authorConway, Elizabeth Len
dc.contributor.authorHowes, L Gen
dc.contributor.authorMaccarrone, Cen
dc.contributor.authorBeart, P Men
dc.contributor.authorJarrott, Ben
dc.date.accessioned2015-05-16T02:39:18Z
dc.date.available2015-05-16T02:39:18Z
dc.date.issued1987-08-01en
dc.identifier.citationCanadian Journal of Physiology and Pharmacology; 65(8): 1633-7en
dc.identifier.govdoc2961419en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12903en
dc.description.abstractStudies of the roles played by neurotransmitters in the development of hypertension in the spontaneously hypertensive (SHR) rat are complicated by the presence of genetic differences between SHR and normotensive control rats, which are not related to differences in blood pressure. One approach that may be used in an attempt to overcome this difficulty is to study the manner in which neurotransmitter and metabolite levels change with age, and to relate these changes to alterations in blood pressure with ageing. Noradrenaline (NA) levels in the brainstem and spinal cord of SHR and Wistar Kyoto rats fell with age, while 3,4-dihydroxyphenylethyleneglycol (DHPG) levels (a neuronal metabolite of noradrenaline) remained constant. Similar changes were seen when NA and DHPG levels were measured in the discrete brainstem A1, A2, and C2 region, and when adrenaline, NA, and DHPG levels were examined in the C1 region. Differences in age-related changes of neuropeptide Y (NPY) levels were also found in the ventromedial nucleus of the hypothalamus and the locus coeruleus, and of beta-endorphin in the anterior hypothalamic nucleus, the paragigantocellular nucleus of the brainstem, and the locus coeruleus. These changes may indicate either a progressive increase in the activity of neurons in the sympathoexcitatory C1 region or a progressive reduction in the activity of vasodepressor A1, A2, and C2 regions with ageing, or both. However, changes in catecholamines and metabolites with age were similar in both strains and therefore cannot readily explain the more rapid rise in blood pressure with ageing in SHR rats.en
dc.language.isoenen
dc.subject.otherAgingen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressureen
dc.subject.otherBrain.growth & developmenten
dc.subject.otherBrain Stem.growth & developmenten
dc.subject.otherEpinephrine.metabolismen
dc.subject.otherHypothalamus.growth & developmenten
dc.subject.otherNeuropeptide Y.metabolismen
dc.subject.otherNorepinephrine.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHR.growth & developmenten
dc.subject.otherRats, Inbred Strains.growth & developmenten
dc.subject.otherRats, Inbred WKY.growth & developmenten
dc.subject.otherReference Valuesen
dc.subject.otherbeta-Endorphin.metabolismen
dc.titleNeurotransmitters and neuropeptides in blood pressure regulation in the spontaneously hypertensive rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleCanadian journal of physiology and pharmacologyen
dc.identifier.affiliationDepartment of Medicine and Clinical Pharmacology, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages1633-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2961419en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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