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Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease. |
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| Abstract |
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The pharmacokinetic properties of a single oral dose of 100 mg of tiapride were studied in six patients with Huntington's disease. The results for five patients were consistent with a two compartment open model. Peak plasma concentrations were observed within 2 h following drug administration with a mean value of 0.92 micrograms/ml being recorded. The drug was rapidly eliminated as unmetabolised tiapride in the urine, 51% of the dose was recovered in 24 h. The plasma elimination half-life was 5.3 h and the average apparent plasma clearance was 16.6 l/h. |
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European Journal of Clinical Pharmacology; 32(6): 583-6 |
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European journal of clinical pharmacology |
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