Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12900
Title: Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease.
Austin Authors: Norman, Trevor R ;Chiu, E;James, R H;Gregory, M S
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1987
Publication information: European Journal of Clinical Pharmacology; 32(6): 583-6
Abstract: The pharmacokinetic properties of a single oral dose of 100 mg of tiapride were studied in six patients with Huntington's disease. The results for five patients were consistent with a two compartment open model. Peak plasma concentrations were observed within 2 h following drug administration with a mean value of 0.92 micrograms/ml being recorded. The drug was rapidly eliminated as unmetabolised tiapride in the urine, 51% of the dose was recovered in 24 h. The plasma elimination half-life was 5.3 h and the average apparent plasma clearance was 16.6 l/h.
Gov't Doc #: 2958291
URI: http://ahro.austin.org.au/austinjspui/handle/1/12900
URL: https://pubmed.ncbi.nlm.nih.gov/2958291
Type: Journal Article
Subjects: Administration, Oral
Adult
Aged
Benzamides.pharmacokinetics
Female
Half-Life
Humans
Huntington Disease.metabolism
Kidney.metabolism
Male
Middle Aged
Tiapamil Hydrochloride.pharmacokinetics
Appears in Collections:Journal articles

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