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Title: Genetic hypertension accelerates nephropathy in the streptozotocin diabetic rat.
Austin Authors: Cooper, Mark E;Allen, Terri J;Macmillan, P;Bach, Leon A;Jerums, George ;Doyle, A E
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria.
Issue Date: 1-Jan-1988
Publication information: American Journal of Hypertension; 1(1): 5-10
Abstract: To evaluate whether hypertension is a cause or just an association with diabetic renal disease, diabetes was induced in both normotensive Wistar-Kyoto and spontaneously hypertensive rats (WKY and SHR). Animals were assessed monthly for 8 months before sacrifice. When compared to normotensive diabetic rats (WKY-STZ), hypertensive diabetic rats (SHR-STZ) had an earlier and more rapid rise in urinary albumin excretion. In addition, SHR-STZ had increased glomerular basement membrane thickness when compared to WKY-STZ or SHR. In a separate experiment, Enalapril therapy (35 mg/L) was administered in drinking water to WKY-STZ and SHR-STZ. Enalapril significantly reduced blood pressure in both animal groups, and this was associated with a decrease in urinary albumin excretion. The SHR-STZ model has accelerated nephropathy as determined by both functional and structural parameters. Angiotensin-converting enzyme inhibition is associated with a reduction in albuminuria in both hypertensive and normotensive models of diabetic nephropathy.
Gov't Doc #: 2835966
Journal: American Journal of Hypertension
Type: Journal Article
Subjects: Albuminuria.prevention & control
Analysis of Variance
Blood Pressure.drug effects
Diabetes Mellitus, Experimental.urine
Diabetic Nephropathies.etiology.urine
Disease Models, Animal
Enalapril.pharmacology.therapeutic use
Glomerular Filtration Rate.drug effects
Hypertension.drug therapy.genetics
Rats, Inbred SHR
Rats, Inbred WKY
Time Factors
Appears in Collections:Journal articles

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