Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12858
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dc.contributor.authorCooper, Mark Een
dc.contributor.authorAllen, Terri Jen
dc.contributor.authorMacmillan, Pen
dc.contributor.authorBach, Leon Aen
dc.contributor.authorJerums, Georgeen
dc.contributor.authorDoyle, A Een
dc.date.accessioned2015-05-16T02:36:23Z
dc.date.available2015-05-16T02:36:23Z
dc.date.issued1988-01-01en
dc.identifier.citationAmerican Journal of Hypertension; 1(1): 5-10en
dc.identifier.govdoc2835966en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/12858en
dc.description.abstractTo evaluate whether hypertension is a cause or just an association with diabetic renal disease, diabetes was induced in both normotensive Wistar-Kyoto and spontaneously hypertensive rats (WKY and SHR). Animals were assessed monthly for 8 months before sacrifice. When compared to normotensive diabetic rats (WKY-STZ), hypertensive diabetic rats (SHR-STZ) had an earlier and more rapid rise in urinary albumin excretion. In addition, SHR-STZ had increased glomerular basement membrane thickness when compared to WKY-STZ or SHR. In a separate experiment, Enalapril therapy (35 mg/L) was administered in drinking water to WKY-STZ and SHR-STZ. Enalapril significantly reduced blood pressure in both animal groups, and this was associated with a decrease in urinary albumin excretion. The SHR-STZ model has accelerated nephropathy as determined by both functional and structural parameters. Angiotensin-converting enzyme inhibition is associated with a reduction in albuminuria in both hypertensive and normotensive models of diabetic nephropathy.en
dc.language.isoenen
dc.subject.otherAlbuminuria.prevention & controlen
dc.subject.otherAnalysis of Varianceen
dc.subject.otherAnimalsen
dc.subject.otherBlood Pressure.drug effectsen
dc.subject.otherDiabetes Mellitus, Experimental.urineen
dc.subject.otherDiabetic Nephropathies.etiology.urineen
dc.subject.otherDisease Models, Animalen
dc.subject.otherEnalapril.pharmacology.therapeutic useen
dc.subject.otherGlomerular Filtration Rate.drug effectsen
dc.subject.otherHypertension.drug therapy.geneticsen
dc.subject.otherMaleen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred SHRen
dc.subject.otherRats, Inbred WKYen
dc.subject.otherStreptozocinen
dc.subject.otherTime Factorsen
dc.titleGenetic hypertension accelerates nephropathy in the streptozotocin diabetic rat.en
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Hypertensionen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg, Victoria.en
dc.description.pages5-10en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2835966en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.cerifentitytypePublications-
crisitem.author.deptEndocrinology-
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