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https://ahro.austin.org.au/austinjspui/handle/1/12677| Title: | Structural biology of antibody recognition of carbohydrate epitopes and potential uses for targeted cancer immunotherapies. | Austin Authors: | Dingjan, Tamir;Spendlove, Ian;Durrant, Lindy G;Scott, Andrew M ;Yuriev, Elizabeth;Ramsland, Paul A | Affiliation: | Tumour Targeting Laboratory, Olivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia Faculty of Medicine, University of Melbourne, Melbourne, Victoria, Australia Centre for Biomedical Research, Burnet Institute, Melbourne, VIC 3004, Australia Department of Immunology, Monash University, Alfred Medical Research and Education Precinct, Melbourne, VIC 3004, Australia Department of Surgery Austin Health, University of Melbourne, Heidelberg, VIC 3084, Australia School of Cancer Medicine, La Trobe University, Melbourne, Victoria, Australia School of Biomedical Sciences, CHIRI Biosciences, Curtin University, Perth, WA 6845, Australia Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia Academic Department of Clinical Oncology, Division of Cancer and Stem cells, University of Nottingham, City Hospital, Nottingham NG5 1PB, United Kingdom. |
Issue Date: | 7-Mar-2015 | Publication information: | Molecular Immunology 2015; 67(2 Pt A): 75-88 | Abstract: | Monoclonal antibodies represent the most successful class of biopharmaceuticals for the treatment of cancer. Mechanisms of action of therapeutic antibodies are very diverse and reflect their ability to engage in antibody-dependent effector mechanisms, internalize to deliver cytotoxic payloads, and display direct effects on cells by lysis or by modulating the biological pathways of their target antigens. Importantly, one of the universal changes in cancer is glycosylation and carbohydrate-binding antibodies can be produced to selectively recognize tumor cells over normal tissues. A promising group of cell surface antibody targets consists of carbohydrates presented as glycolipids or glycoproteins. In this review, we outline the basic principles of antibody-based targeting of carbohydrate antigens in cancer. We also present a detailed structural view of antibody recognition and the conformational properties of a series of related tissue-blood group (Lewis) carbohydrates that are being pursued as potential targets of cancer immunotherapy. | Gov't Doc #: | 25757815 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12677 | DOI: | 10.1016/j.molimm.2015.02.028 | Journal: | Molecular immunology | URL: | https://pubmed.ncbi.nlm.nih.gov/25757815 | Type: | Journal Article | Subjects: | Antibody tumor targeting Blood group carbohydrates Cancer immunotherapy Carbohydrate conformations Carbohydrate recognition Protein–carbohydrate interactions |
| Appears in Collections: | Journal articles |
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