Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12659
Title: Alpha blockers and vasodilating beta blockers--influence on factors involved in the pathogenesis of vascular disease in patients with hypertension.
Austin Authors: Louis, William J ;Drummer, Olaf H;Howes, L G
Affiliation: Department of Clinical Pharmacology & Therapeutics, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1989
Publication information: Clinical and Experimental Hypertension. Part A, Theory and Practice; 11(5-6): 1075-83
Abstract: Antihypertensive drugs that interact with adrenoceptors have certain advantages and disadvantages (on the treatment of hypertension). Alpha-1 antagonists such as prazosin have favorable effects on plasma lipids but may produce excessive postural falls in blood pressure, particularly following the initial dose. Recently developed alpha-1 antagonists (doxazosin, terazosin) have longer durations of action than prazosin, allowing less frequent administration. Beta blockers may be cardioprotective but in contrast to alpha-1 antagonists tend to have adverse effects on plasma lipids. Drugs with combined beta and alpha-1 blocking activity such as labetalol have favorable metabolic effects but postural hypotension remains a problem. Recently developed drugs with different alpha-1/beta blocking ratios that differ from labetalol may prove to be more popular clinically. Several beta blockers with vasodilator activity which is not due to alpha-1 blockade have also been developed. These drugs appear to have favorable metabolic effects similar to drugs with alpha-1 blocking activity, but do not cause postural hypotension.
Gov't Doc #: 2571433
URI: https://ahro.austin.org.au/austinjspui/handle/1/12659
Journal: Clinical and experimental hypertension. Part A, Theory and practice
URL: https://pubmed.ncbi.nlm.nih.gov/2571433
Type: Journal Article
Subjects: Adrenergic alpha-Antagonists.therapeutic use
Adrenergic beta-Antagonists.therapeutic use
Antihypertensive Agents.adverse effects.therapeutic use
Humans
Hypertension.blood.complications.drug therapy
Lipids.blood
Vascular Diseases.etiology.prevention & control
Vasodilator Agents.therapeutic use
Appears in Collections:Journal articles

Show full item record

Page view(s)

12
checked on Oct 4, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.