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Title: Alpha blockers and vasodilating beta blockers--influence on factors involved in the pathogenesis of vascular disease in patients with hypertension.
Austin Authors: Louis, William J ;Drummer, Olaf H;Howes, L G
Affiliation: Department of Clinical Pharmacology & Therapeutics, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 16-May-1989
Publication information: Clinical and Experimental Hypertension. Part A, Theory and Practice; 11(5-6): 1075-83
Abstract: Antihypertensive drugs that interact with adrenoceptors have certain advantages and disadvantages (on the treatment of hypertension). Alpha-1 antagonists such as prazosin have favorable effects on plasma lipids but may produce excessive postural falls in blood pressure, particularly following the initial dose. Recently developed alpha-1 antagonists (doxazosin, terazosin) have longer durations of action than prazosin, allowing less frequent administration. Beta blockers may be cardioprotective but in contrast to alpha-1 antagonists tend to have adverse effects on plasma lipids. Drugs with combined beta and alpha-1 blocking activity such as labetalol have favorable metabolic effects but postural hypotension remains a problem. Recently developed drugs with different alpha-1/beta blocking ratios that differ from labetalol may prove to be more popular clinically. Several beta blockers with vasodilator activity which is not due to alpha-1 blockade have also been developed. These drugs appear to have favorable metabolic effects similar to drugs with alpha-1 blocking activity, but do not cause postural hypotension.
Gov't Doc #: 2571433
Type: Journal Article
Subjects: Adrenergic alpha-Antagonists.therapeutic use
Adrenergic beta-Antagonists.therapeutic use
Antihypertensive Agents.adverse effects.therapeutic use
Hypertension.blood.complications.drug therapy
Vascular Diseases.etiology.prevention & control
Vasodilator Agents.therapeutic use
Appears in Collections:Journal articles

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