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dc.contributor.authorLouis, William Jen
dc.contributor.authorDrummer, Olaf Hen
dc.contributor.authorHowes, L Gen
dc.identifier.citationClinical and Experimental Hypertension. Part A, Theory and Practice; 11(5-6): 1075-83en
dc.description.abstractAntihypertensive drugs that interact with adrenoceptors have certain advantages and disadvantages (on the treatment of hypertension). Alpha-1 antagonists such as prazosin have favorable effects on plasma lipids but may produce excessive postural falls in blood pressure, particularly following the initial dose. Recently developed alpha-1 antagonists (doxazosin, terazosin) have longer durations of action than prazosin, allowing less frequent administration. Beta blockers may be cardioprotective but in contrast to alpha-1 antagonists tend to have adverse effects on plasma lipids. Drugs with combined beta and alpha-1 blocking activity such as labetalol have favorable metabolic effects but postural hypotension remains a problem. Recently developed drugs with different alpha-1/beta blocking ratios that differ from labetalol may prove to be more popular clinically. Several beta blockers with vasodilator activity which is not due to alpha-1 blockade have also been developed. These drugs appear to have favorable metabolic effects similar to drugs with alpha-1 blocking activity, but do not cause postural hypotension.en
dc.subject.otherAdrenergic alpha-Antagonists.therapeutic useen
dc.subject.otherAdrenergic beta-Antagonists.therapeutic useen
dc.subject.otherAntihypertensive Agents.adverse effects.therapeutic useen
dc.subject.otherHypertension.blood.complications.drug therapyen
dc.subject.otherVascular Diseases.etiology.prevention & controlen
dc.subject.otherVasodilator Agents.therapeutic useen
dc.titleAlpha blockers and vasodilating beta blockers--influence on factors involved in the pathogenesis of vascular disease in patients with hypertension.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical and experimental hypertension. Part A, Theory and practiceen
dc.identifier.affiliationDepartment of Clinical Pharmacology & Therapeutics, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Pharmacology and Therapeutics-
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