Please use this identifier to cite or link to this item:
Title: Feasibility study and pilot randomised trial of an antenatal depression treatment with infant follow-up.
Austin Authors: Milgrom, Jeannette ;Holt, Charlene ;Holt, Christopher J;Ross, Jessica;Ericksen, Jennifer ;Gemmill, Alan W 
Affiliation: Parent-Infant Research Institute, Austin Health, 300 Waterdale Road, Heidelberg West, VIC, 3081, Australia
Issue Date: 24-Feb-2015
Publication information: Archives of Women's Mental Health 2015; 18(5): 717-30
Abstract: Substantial evidence links antenatal depression, anxiety and stress with negative effects on foetal development, resulting in enduring problems in child development. Despite this, there is a paucity of research on intervention programmes designed to address depression and anxiety, and none that include infant outcomes. We aimed to evaluate the efficacy of a brief treatment for maternal depression and anxiety in pregnancy in a sample of women with a diagnosed depressive disorder. We developed a cognitive behavioural therapy treatment for antenatal depression and anxiety and evaluated it in a feasibility trial. This was followed by a pilot randomised controlled trial (RCT) which collected data on the efficacy of the brief intervention and follow-up data on infants. The feasibility study (n = 25) yielded promising results for adherence, acceptability and improvements in depression and anxiety (Beck Depression Inventory and Beck Anxiety Inventory). The RCT (n = 54) again showed excellent adherence and acceptability and supported the efficacy of the treatment. Strong reductions in anxiety were observed during pregnancy, and improvements in depression were maintained at 9 months representing a moderately large effect size. Nine-month infant outcomes showed several medium to large effects favouring the intervention in domains including problem solving, self-regulation and stress reactivity, which were independent of maternal postnatal mood. Treating severe depression and anxiety during pregnancy with a brief cognitive behavioural therapy (CBT) intervention appears feasible and worthwhile. To reliably detect clinically meaningful effects on infant outcomes, larger RCTs are likely to be required.
Gov't Doc #: 25709044
DOI: 10.1007/s00737-015-0512-5
ORCID: 0000-0002-4082-4595
Journal: Archives of women's mental health
Type: Journal Article
Appears in Collections:Journal articles

Files in This Item:
File SizeFormat 
25709044.pdf66.74 kBAdobe PDFView/Open
Show full item record


checked on Jan 30, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.