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|Title:||Feasibility study and pilot randomised trial of an antenatal depression treatment with infant follow-up.||Austin Authors:||Milgrom, Jeannette ;Holt, Charlene ;Holt, Christopher J;Ross, Jessica;Ericksen, Jennifer ;Gemmill, Alan W||Affiliation:||Parent-Infant Research Institute, Austin Health, 300 Waterdale Road, Heidelberg West, VIC, 3081, Australia||Issue Date:||24-Feb-2015||Publication information:||Archives of Women's Mental Health 2015; 18(5): 717-30||Abstract:||Substantial evidence links antenatal depression, anxiety and stress with negative effects on foetal development, resulting in enduring problems in child development. Despite this, there is a paucity of research on intervention programmes designed to address depression and anxiety, and none that include infant outcomes. We aimed to evaluate the efficacy of a brief treatment for maternal depression and anxiety in pregnancy in a sample of women with a diagnosed depressive disorder. We developed a cognitive behavioural therapy treatment for antenatal depression and anxiety and evaluated it in a feasibility trial. This was followed by a pilot randomised controlled trial (RCT) which collected data on the efficacy of the brief intervention and follow-up data on infants. The feasibility study (n = 25) yielded promising results for adherence, acceptability and improvements in depression and anxiety (Beck Depression Inventory and Beck Anxiety Inventory). The RCT (n = 54) again showed excellent adherence and acceptability and supported the efficacy of the treatment. Strong reductions in anxiety were observed during pregnancy, and improvements in depression were maintained at 9 months representing a moderately large effect size. Nine-month infant outcomes showed several medium to large effects favouring the intervention in domains including problem solving, self-regulation and stress reactivity, which were independent of maternal postnatal mood. Treating severe depression and anxiety during pregnancy with a brief cognitive behavioural therapy (CBT) intervention appears feasible and worthwhile. To reliably detect clinically meaningful effects on infant outcomes, larger RCTs are likely to be required.||Gov't Doc #:||25709044||URI:||http://ahro.austin.org.au/austinjspui/handle/1/12656||DOI:||10.1007/s00737-015-0512-5||ORCID:||0000-0002-4082-4595||URL:||https://pubmed.ncbi.nlm.nih.gov/25709044||Type:||Journal Article|
|Appears in Collections:||Journal articles|
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