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Title: Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease.
Austin Authors: Kerbler, Georg M;Fripp, Jürgen;Rowe, Christopher C ;Villemagne, Victor L ;Salvado, Olivier;Rose, Stephen;Coulson, Elizabeth J
Institutional Author: Alzheimer's Disease Neuroimaging Initiative
Affiliation: Commonwealth Scientific and Industrial Research Organisation, Computational Informatics, Brisbane, Qld 4029, Australia
Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, The University of Queensland, Brisbane, Qld 4072, Australia
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Vic. 3084, Australia
Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australia
3084, Australia
Issue Date: 27-Nov-2014
Publication information: Neuroimage. Clinical 2014; 7(): 105-13
Abstract: The brains of patients suffering from Alzheimer's disease (AD) have three classical pathological hallmarks: amyloid-beta (Aβ) plaques, tau tangles, and neurodegeneration, including that of cholinergic neurons of the basal forebrain. However the relationship between Aβ burden and basal forebrain degeneration has not been extensively studied. To investigate this association, basal forebrain volumes were determined from magnetic resonance images of controls, subjects with amnestic mild cognitive impairment (aMCI) and AD patients enrolled in the longitudinal Alzheimer's Disease Neuroimaging Initiative (ADNI) and Australian Imaging, Biomarkers and Lifestyle (AIBL) studies. In the AIBL cohort, these volumes were correlated within groups to neocortical gray matter retention of Pittsburgh compound B (PiB) from positron emission tomography images as a measure of Aβ load. The basal forebrain volumes of AD and aMCI subjects were significantly reduced compared to those of control subjects. Anterior basal forebrain volume was significantly correlated to neocortical PiB retention in AD subjects and aMCI subjects with high Aβ burden, whereas posterior basal forebrain volume was significantly correlated to neocortical PiB retention in control subjects with high Aβ burden. Therefore this study provides new evidence for a correlation between neocortical Aβ accumulation and basal forebrain degeneration. In addition, cluster analysis showed that subjects with a whole basal forebrain volume below a determined cut-off value had a 7 times higher risk of having a worse diagnosis within ~18 months.
Gov't Doc #: 25610772
DOI: 10.1016/j.nicl.2014.11.015
Journal: NeuroImage. Clinical
Type: Journal Article
Subjects: 3D, 3-dimensional
AD, Alzheimer's disease
ADNI, Alzheimer's Disease Neuroimaging Initiative
AIBL, Australian Imaging, Biomarkers and Lifestyle Flagship Study of Aging
Alzheimer's disease
Aβ, amyloid-beta
Basal forebrain
CSF, cerebrospinal fluid
GM, gray matter
HC, healthy control
MCI, mild cognitive impairment
MNI, Montreal Neurological Institute
MPM, maximum probability maps
MPRAGE, magnetization prepared rapid gradient echo
MRI, magnetic resonance imaging
Magnetic resonance imaging
OR, odds ratio
PET, positron emission tomography
PiB, Pittsburgh compound B
SPSS, statistics software package for the social sciences
SUVR, standard uptake value ratio
SyN, symmetric normalization
T1W, T1-weighted
TG-ROC, two-graph receiver operating characteristic
WM, white matter
aMCI, amnestic mild cognitive impairment
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