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dc.contributor.authorKerbler, Georg Men
dc.contributor.authorFripp, Jürgenen
dc.contributor.authorRowe, Christopher Cen
dc.contributor.authorVillemagne, Victor Len
dc.contributor.authorSalvado, Olivieren
dc.contributor.authorRose, Stephenen
dc.contributor.authorCoulson, Elizabeth Jen
dc.identifier.citationNeuroimage. Clinical 2014; 7(): 105-13en
dc.description.abstractThe brains of patients suffering from Alzheimer's disease (AD) have three classical pathological hallmarks: amyloid-beta (Aβ) plaques, tau tangles, and neurodegeneration, including that of cholinergic neurons of the basal forebrain. However the relationship between Aβ burden and basal forebrain degeneration has not been extensively studied. To investigate this association, basal forebrain volumes were determined from magnetic resonance images of controls, subjects with amnestic mild cognitive impairment (aMCI) and AD patients enrolled in the longitudinal Alzheimer's Disease Neuroimaging Initiative (ADNI) and Australian Imaging, Biomarkers and Lifestyle (AIBL) studies. In the AIBL cohort, these volumes were correlated within groups to neocortical gray matter retention of Pittsburgh compound B (PiB) from positron emission tomography images as a measure of Aβ load. The basal forebrain volumes of AD and aMCI subjects were significantly reduced compared to those of control subjects. Anterior basal forebrain volume was significantly correlated to neocortical PiB retention in AD subjects and aMCI subjects with high Aβ burden, whereas posterior basal forebrain volume was significantly correlated to neocortical PiB retention in control subjects with high Aβ burden. Therefore this study provides new evidence for a correlation between neocortical Aβ accumulation and basal forebrain degeneration. In addition, cluster analysis showed that subjects with a whole basal forebrain volume below a determined cut-off value had a 7 times higher risk of having a worse diagnosis within ~18 months.en
dc.subject.other3D, 3-dimensionalen
dc.subject.otherAD, Alzheimer's diseaseen
dc.subject.otherADNI, Alzheimer's Disease Neuroimaging Initiativeen
dc.subject.otherAIBL, Australian Imaging, Biomarkers and Lifestyle Flagship Study of Agingen
dc.subject.otherAlzheimer's diseaseen
dc.subject.otherAβ, amyloid-betaen
dc.subject.otherBasal forebrainen
dc.subject.otherCSF, cerebrospinal fluiden
dc.subject.otherGM, gray matteren
dc.subject.otherHC, healthy controlen
dc.subject.otherMCI, mild cognitive impairmenten
dc.subject.otherMNI, Montreal Neurological Instituteen
dc.subject.otherMPM, maximum probability mapsen
dc.subject.otherMPRAGE, magnetization prepared rapid gradient echoen
dc.subject.otherMRI, magnetic resonance imagingen
dc.subject.otherMagnetic resonance imagingen
dc.subject.otherOR, odds ratioen
dc.subject.otherPET, positron emission tomographyen
dc.subject.otherPiB, Pittsburgh compound Ben
dc.subject.otherSPSS, statistics software package for the social sciencesen
dc.subject.otherSUVR, standard uptake value ratioen
dc.subject.otherSyN, symmetric normalizationen
dc.subject.otherT1W, T1-weighteden
dc.subject.otherTG-ROC, two-graph receiver operating characteristicen
dc.subject.otherWM, white matteren
dc.subject.otheraMCI, amnestic mild cognitive impairmenten
dc.titleBasal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroImage. Clinicalen
dc.identifier.affiliationCommonwealth Scientific and Industrial Research Organisation, Computational Informatics, Brisbane, Qld 4029, Australiaen
dc.identifier.affiliationQueensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, The University of Queensland, Brisbane, Qld 4072, Australiaen
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Vic. 3084, Australiaen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliation3084, Australiaen
dc.contributor.corpauthorAlzheimer's Disease Neuroimaging Initiativeen
dc.type.austinJournal Articleen, Christopher C
item.fulltextNo Fulltext-
item.openairetypeJournal Article- Imaging and Therapy- Imaging and Therapy-
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