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https://ahro.austin.org.au/austinjspui/handle/1/12511| Title: | Platelet serotonin uptake and 3H-imipramine binding in panic disorder. | Austin Authors: | Norman, Trevor R ;Sartor, Daniela M;Judd, F K;Burrows, Graham D;Gregory, M S;McIntyre, I M | Affiliation: | Department of Psychiatry, University of Melbourne, Austin Hospital, Victoria, Australia | Issue Date: | 8-Jul-1989 | Publication information: | Journal of Affective Disorders; 17(1): 77-81 | Abstract: | Platelet serotonin uptake and 3H-imipramine binding were measured in eight patients with panic disorders and nine controls. The Vmax of serotonin uptake was significantly elevated in patients compared to controls (77 +/- 14 vs. 50 +/- 4 pmol/10(8) platelets/min; P less than 0.05) while Km values were not different (1.46 +/- 0.41 vs. 1.24 +/- 0.20 microM). 3H-Imipramine binding to ruptured platelet membranes was not significantly different between patients and controls for either Bmax (395 +/- 71 vs. 412 +/- 107 fmol/mg protein) or Kd (0.90 +/- 0.18 vs. 1.09 +/- 0.30 nM). The implications for a serotonergic dysfunction in panic disorders are discussed. | Gov't Doc #: | 2544638 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12511 | Journal: | Journal of affective disorders | URL: | https://pubmed.ncbi.nlm.nih.gov/2544638 | Type: | Journal Article | Subjects: | Adult Agoraphobia.blood Blood Platelets.metabolism Carrier Proteins Fear.physiology Female Humans Imipramine.pharmacokinetics Male Panic.physiology Phobic Disorders.blood Receptors, Drug Receptors, Neurotransmitter.metabolism Serotonin.blood |
| Appears in Collections: | Journal articles |
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