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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12511
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dc.contributor.authorNorman, Trevor Ren
dc.contributor.authorSartor, Daniela Men
dc.contributor.authorJudd, F Ken
dc.contributor.authorBurrows, Graham Den
dc.contributor.authorGregory, M Sen
dc.contributor.authorMcIntyre, I Men
dc.date.accessioned2015-05-16T02:13:07Z
dc.date.available2015-05-16T02:13:07Z
dc.date.issued1989-07-08en
dc.identifier.citationJournal of Affective Disorders; 17(1): 77-81en
dc.identifier.govdoc2544638en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12511en
dc.description.abstractPlatelet serotonin uptake and 3H-imipramine binding were measured in eight patients with panic disorders and nine controls. The Vmax of serotonin uptake was significantly elevated in patients compared to controls (77 +/- 14 vs. 50 +/- 4 pmol/10(8) platelets/min; P less than 0.05) while Km values were not different (1.46 +/- 0.41 vs. 1.24 +/- 0.20 microM). 3H-Imipramine binding to ruptured platelet membranes was not significantly different between patients and controls for either Bmax (395 +/- 71 vs. 412 +/- 107 fmol/mg protein) or Kd (0.90 +/- 0.18 vs. 1.09 +/- 0.30 nM). The implications for a serotonergic dysfunction in panic disorders are discussed.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgoraphobia.blooden
dc.subject.otherBlood Platelets.metabolismen
dc.subject.otherCarrier Proteinsen
dc.subject.otherFear.physiologyen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherImipramine.pharmacokineticsen
dc.subject.otherMaleen
dc.subject.otherPanic.physiologyen
dc.subject.otherPhobic Disorders.blooden
dc.subject.otherReceptors, Drugen
dc.subject.otherReceptors, Neurotransmitter.metabolismen
dc.subject.otherSerotonin.blooden
dc.titlePlatelet serotonin uptake and 3H-imipramine binding in panic disorder.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of affective disordersen
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, Austin Hospital, Victoria, Australiaen
dc.description.pages77-81en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2544638en
dc.type.austinJournal Articleen
local.name.researcherNorman, Trevor R
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptPsychiatry (University of Melbourne)-
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